载脂蛋白B基因Xba Ⅰ多态性与新生儿血脂、载脂蛋白水平的关系  

RELATION BETWEEN THE APOLIPOPROTEIN B GENE Xba ⅠPOLYMORPHISM AND SERUM LIPIDS,APOLIPOPROTEINS IN HEALTHY CHINESE NEWBORNS

作　　者：陈能[1] 吴淑群[1] 张水堂[1] 刘仲熊[1] 田鸾英[1] 

机构地区：[1]湖北医科大学附一院儿科

出　　处：《中华医学遗传学杂志》1997年第6期358-361,共4页Chinese Journal of Medical Genetics

摘　　要：为探讨ａｐｏＢ基因ＸｂａⅠ多态性与新生儿、载脂蛋白水平的关系。应用多聚酶链反应（ＰＣＲ）研究了３１例有冠心病家族史（观察组）、９２例无冠心病家族史（对照组）足月健康新生儿载脂蛋白Ｂ（ａｐｏＢ）基因ＸｂａⅠ酶切位点的限制性片段长度多态性（ＲＦＬＰ）及其与血脂的关系。结果显示：两组间少见的Ｘ＋等位基因频率无显著性差异，但具有Ｘ＋Ｘ－基因型者，ＨＤＬ－Ｃ水平低于Ｘ－Ｘ－基因型者（Ｐ＜０．０５），观察组与对照组血脂比较，前者ａｐｏＢ水平升高（Ｐ＜０．０１）。说明：Ｘ＋等位基因与血脂改变有关，它是心血管疾病的一个危险因素，具有冠心病家族史及Ｘ＋基因型的新生儿较其它新生儿更易罹患心血管疾病。Using the polymerase chain reaction(PCR),We studied the relation between the apolipoprotein B(apo B) gene XbaⅠpolymorphism and serum lipid,apolipoprotein levels in 31 healthy newborns with a grandparental history of coronary heart disease,92 newborns without such a history.The results showed that no significant difference was noted between the two groups in the frequency of rare X+ allele,but X+X- genotype was associated with lower level of HDLC,compared with X-X- genotype (P<005).The level of apo B in the group with coronary heart disease family history was significantly higher than that in the group without such a history (P<0001) The study demonstrates that X+ allele as one of the risk factors is associated with the change of serum lipid.Newborns who have cardiovascular disease family history and X+ allele are more liable to cardiovascular disease.

关 键 词：新生儿 载脂蛋白B基因 聚合酶链反应 血脂 

分 类 号：R722.04[医药卫生—儿科]