氟罗沙星与氧氟沙星随机对照治疗细菌性感染228例临床研究  

A randomized controlled clinical study of fleroxacin versus ofloxacin in 228 patients with bacterial infections

作　　者：氟罗沙星临床协作组 张婴元[1] 焦红梅[1] 吴菊芳[1] 汪复[1] 

机构地区：[1]上海医科大学华山医院,200040

出　　处：《中华传染病杂志》1997年第4期214-217,共4页Chinese Journal of Infectious Diseases

摘　　要：为评价氟罗沙星(FLX)的疗效和安全性,以氧氟沙星(OFX)为对照药,在228例细菌性感染病例中进行了随机对照观察,包括尿路感染115例、下呼吸道感染88例和腹腔感染25例。应用 FLX 者115例,OFX 者113例。治疗结果 FLX 和 OFX 组的总有效率分别为83.5%和84.1%,治愈率为67.0%和66.4%;细菌清除率各为85.0%和85.7%。两组的不良反应均轻微,呈一过性,发生率为11.3%(FLX 组)和10.5%(OFX 组),主要为消化道反应。两组差异无显著性。结论:在治疗常见细菌感染时,FLX200～400mg·日^(-1)·次^(-1)与 OFX200～300mg 每日2次,疗程5～14日的治疗方案,其疗效和安全性相仿。In order to evaluate the efficacy and safety of fleroxacin(FLX),a randomized controlled clinical trial of FLX compared with ofloxacin(OFX)was conducted.A total of 228 patients,including 115 urinary tract infections,88 lower respiratory tract infections and 25 peritonitis were enrolled in the study.Of these,115 patients treated with FLX and 113 treated with OFX.The results showed that the total effective rate of FLX and OFX was 83.5% and 84.1%,cure rate was 67.0% and 66.4% respec- tively.The bacterial eradication rate was 85.0% for FLX and 85.7% for OFX.The adverse reactions in both groups were mild and transient with the rate of 11.3% (FLX) and 10.5% (OFX),mainly gas- trointestinal reactions.There was no statistical difference between two groups.In conclusion,FLX 200 -400mg once daily and OFX 200-300mg twice daily for 5-14 days have comparable efficacy and safety in the treatment of common bacterial infections.

关 键 词：细胞性感染 药物疗法 氟罗沙星 氧氟沙星 

分 类 号：R515.05[医药卫生—内科学]