大鼠慢性硒中毒的病理形态学研究  

PATHOMORPHOLOGICAL STUDIES ON CHRONIC SELENIUM POISONING IN WESTAR RATS

作　　者：薛伟光[1] 秦礼让 雷健保[1] 

机构地区：[1]华中农业大学畜牧兽医系

出　　处：《华中农业大学学报》1990年第2期188-193,共6页Journal of Huazhong Agricultural University

摘　　要：对46只大鼠慢性硒中毒的病理形态学变化的研究表明:大鼠的生长受到明显抑制;肝体比值增加;肝、肾、脾、淋巴结等实质器官受害严重。肝脏病变,早期以肝小叶间质血管、肝窦及中央静脉的淤血、肝实质细胞的变性坏死为特征,中后期则以胆管上皮细胞的增生及肝实质细胞的再生为特点;肾脏主要表现为实质的退行性病变;脾脏则以白髓组织的损害为主,后期损伤有所减轻;淋巴结早期以变质、出血为主,并逐渐变为慢性增生性的淋巴结炎。Changes of pathomorphology in experimental chronic selenosis of Wister rats hadbeen studied. Forty six male wister rats, weighing 105-135 grams were divided intotwo groups. Twenty eight rats in the experimental group were fed basal diet supplem-ented with 10 ppm selenium (se) of sodium selenite, while the eighteenrats of controlgroup were only fed with basal diet. Growth performances of rats, the ratio of liver,kidney, spleen weight per 100 gm of body were determined. On necropsy, both grossand histopathological lesions in liver, kidney, spleen and lymph nodes were studied Growth rate in the experimental group was significantly depressed (P<0. 001).Liver and bodyweight ratio was increased (P<0. 01), while kidney and spleen withthe ratio of body weight were increased only at the advanced stage. Gross and histopathological examination revealed that there were marked damagesin liver, kidney, spleen and lymph nodes. Characteristic lesions in the liver wereintralalobular venules and capillary congestion, hepatocellular degeneration and necrosisin early stage. At the advanced stage, epithelium of intrahepatic bile duct proliferationand heptocyte regeneration were the prominent changes. In kidney, there were tubularcell degeneration and necrosis. The major histopathological findings in the spleen.Lymphocytes of white pulp were sparsely distributed, but in the advaned stage thedegree of severity became to be reduced. Hemorrhages and degeneration were commonlesions in lymph nodes. Also, lymph node lesions were gradually replaced by chronicproliferation lymphadenitis.

关 键 词：大鼠 慢性硒中毒 病理形态学 

分 类 号：S858.906.9[农业科学—临床兽医学]