Iron metabolism in the mononuclear phagocyte system  

作　　者：Weina Kong Xianglin Duan Zhenhua Shi Yanzhong Chang 

机构地区：[1]The Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Hebei Normal University, Shijiazhuang 050016, China

出　　处：《Progress in Natural Science:Materials International》2008年第10期1197-1202,共6页自然科学进展·国际材料（英文版）

基　　金：supported by National Natural Science Foundation of China (Grant No.30570957);Natural Science Foundation of Hebei Province (C2006000152,C2006000155);Science Foundation of Hebei Normal University (L2003B15,B200209,B2002010)

摘　　要：The maintenance of body iron homeostasis requires the coordination of multiple regulatory mechanisms of iron metabolism. The mononuclear phagocyte system （MPS, composed of monocytes, macrophages, and their precursor cells） is crucial in the maintenance of iron homeostasis. Recycling of iron is carried out by specialized macrophages via engulfment of aged erythrocytes. The iron stores of macrophages depend on the levels of recovered and exported iron. However, the molecular mechanisms underlying iron homeostasis in macrophages are poorly understood. Recent studies characterizing the function and regulation of natural resistance-associated mac- rophage protein 1 （Nrampl）, divalent metal transporter 1 （DMT1）, HLA-linked hemechromatosis gene （HFE）, ferroportin 1 （FPN1）, and hepcidin are rapidly expanding our knowledge on the molecular level of MPS iron handling. These studies are deepening our under- standing about the molecular mechanism of iron homeostasis and iron-related diseases.身体铁动态平衡的维护要求铁新陈代谢的多重规章的机制的协作。单音的原子吞噬细胞系统(MPS，单核白血球，巨噬细胞，和他们的先锋房间镇静) 在铁动态平衡的维护是关键的。铁再循环被专业化巨噬细胞经由年老的红血球的吞没执行。巨噬细胞的铁店取决于恢复并且出口的铁的层次。然而，在巨噬细胞位于铁动态平衡下面的分子的机制糟糕被理解。描绘自然联系抵抗的巨噬细胞蛋白质 1 的功能和规定(Nramp1 ) 的最近的研究，二价的金属 transporter 1 (DMT1 ) ，连接 HLA 的 hemechromatosis 基因(HFE ) ， ferroportin 1 (FPN1 ) ，并且 hepcidin 很快在 MPS 铁处理的分子的水平上正在扩展我们的知识。这些研究关于铁动态平衡和铁相关的疾病的分子的机制正在加深我们的理解。

关 键 词：Mononuclear phagocyte system CD163 Natural resistance-associated macrophage protein 1 Divalent metal transporter 1 HFE Ferroportin 1 HEPCIDIN 

分 类 号：Q493[生物学—生理学]