Micronuclei rate and hypoxanthine phosphoribosyl transferase mutation in radon-exposed rats  

作　　者：Fengmei Cui Saijun Fan Mingjiang Hu Jihua Nie Hongmei Li Jian Tong 

机构地区：[1]Department of Radiotoxicology, School of Radiation Medicine and Public Health, Suzhou University, Suzhou Industry Park, Ren＇ai Road 199, Suzhou 215123, China

出　　处：《Progress in Natural Science:Materials International》2008年第10期1305-1308,共4页自然科学进展·国际材料（英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant No.30371226);the Young Teacher Foundation of Suzhou University (Grant No.Q3126534).

摘　　要：The genetic changes in rats with radon exposure were studied by the micronucleus technology and detection of hypoxanthine phosphoribosyl transferase （hprt） mutations. The rate of the micronuclei in peripheral blood lymphocytes and tracheal-bronchial epithelial cells in the radon-inhaled rats was higher than that of the controls （P 〈 0.05）. A similar result was obtained from the hprt assay, which showed a higher mutation frequency in radon-exposed rats. Our results suggested that micronuclei rate and hprt deficiency could be used as biomarkers for the genetic changes with radon exposure.在有氡暴露的老鼠的基因变化被微原子核技术和低亚硫酸钠黄质 phosphoribosyl transferase (hprt ) 的察觉学习变化。在外部血淋巴细胞的微原子核和在吸入氡的老鼠的气管支气管的上皮的房间的率比控制的高(P < 0.05 ) 。类似的结果从 hprt 试金被获得，它在暴露氡的老鼠显示出更高的变化频率。我们的结果建议那微原子核率和 hprt 缺乏能与氡暴露为基因变化被用作简历标记。

关 键 词：RADON Tracheal-bronchial epithelial cell Peripheral blood lymphocyte Micronuclei Hypoxanthine phosphoribosyl transferase 

分 类 号：Q691[生物学—生物物理学]