幼年及成年SD大鼠Barrel脑区的变化  

BARREL CORTEX CHANGES IN YOUNGER AND ADULT SPRAGUE-DAWLEY RATS

作　　者：郑小敏[1] 范光丽[1] 范增杰[2] 王跟辈[1] 王晋辉[2] 

机构地区：[1]西北农林科技大学动物医学院,陕西杨凌712100 [2]中国科学院生物物理研究所

出　　处：《解剖学报》2008年第5期645-648,共4页Acta Anatomica Sinica

基　　金：国家973基础研究项目“神经网络功能信号的精确分析计算”(2006CB500804);国家自然科学基金(39670550)资助项目

摘　　要：目的研究幼年和成年SD大鼠Barrel脑区的发育及变化。方法应用细胞色素氧化酶组织化学法研究成年SD鼠Barrel脑区的精确定位,及不同年龄段SD大鼠(出生后20d及3月龄成年SD大鼠)Barrel脑区的发育情况。结果成年SD大鼠的Barrel脑区面积明显小于年轻鼠(P<0.01);发育过程中,Barrel脑区各列之间的间距缩小,尤其是D和E列之间的间距;应用Nissl复染后发现,分隔各个Barrel桶之间的间距缩小,且神经元数目减少;成年SD大鼠的Barrel桶中高活性细胞色素氧化酶细胞比例明显高于年轻鼠(P<0.01)。结论啮齿类动物躯体感觉皮层Barrel脑区神经网络的排布精细,其构筑在发育过程中存在着微妙的变化。Objective To study the development and changes of the Barrel Cortex in younger and adult SD rats. Methods Cytochrome oxydase histochemistry and Nissl＇ s counterstaining were applied to locate the encephalic region of Barrel in adult rats, and Barrel cortex changes in different ages were analyzed（postnatal 20 days and postnatal 3 months）. Results During the development of Barrel cortex, an obvious area change was found（ P 〈 0.01 ）. The space between Barrel rows shrinked and the number of neurons in septa decreased. Compared with that of younger Sprague-Dawley rats, the Barrel cortex of adult Sprague- Dawley rats had more cytochrome oxydase highly active neurons （P 〈 0.01 ）. Conclusion Subtle changes exist during the development in the fine assignment and structure of Barrel cortex neural network in rodent rats.

关 键 词：Barrel脑区 胡须 细胞色素氧化酶组织化学法 大鼠 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]