替硝唑在汉族健康人体的药动学  

Pharmacokinetics of Tinidazole in Chinese Healthy Volunteers

作　　者：郭涛[1] 常馨予[1] 夏东亚[1] 

机构地区：[1]沈阳军区总医院药剂科,沈阳110016

出　　处：《中国药学杂志》2008年第17期1336-1338,共3页Chinese Pharmaceutical Journal

基　　金：全军医学科学技术研究“十一五”计划科技攻关课题基金资助项目(06G023)

摘　　要：目的研究汉族健康志愿者单剂量po替硝唑片的药动学。方法健康志愿者10名(其中男性5名,女性5名),单剂量po替硝唑片剂1 g,采用高效液相色谱法测定血浆中替硝唑的含量。用DAS软件程序进行数据处理,用SPSS软件对不同性别药动学参数进行统计分析。结果受试者单剂量po1 g替硝唑的主要药动学参数:ρmax为(19.04±2.42)mg·L-1,tmax为(2.15±0.47)h,t1/2为(16.94±2.40)h,AUC0-72 h为(454.37±59.74)mg·h·L-1,AUC0-∞为(486.14±65.63)mg·h·L-1。结论汉族健康志愿者单剂量po替硝唑片的体内药动学过程符合一室模型。经统计学分析,汉族健康志愿者药动学过程存在性别差异。OBJECTIVE To study the pharmacokinetics of tinidazole tablets after a single oral dose in Han healthy volunteers.METHODS Five healthy male volunteers and five healthy female volunteers were involved in the study.Each subject received a single dose of 1 g tinidazole tablets.The plasma concentration was determined by HPLC.The pharmacokinetic parameters were calculated by DAS software and were statistical analyzed by SPSS software.RESULTS The main pharmacokinetic parameters were as follows： ρmax was（19.04±2.42） mg·L-1,tmax was（2.15±0.47） h,t1/2 was（16.94±2.40） h,AUC0-72 h was（454.37±59.74） mg·h·L-1,AUC0-∞ was（486.14±65.63） mg·h·L^-1.CONCLUSION The results showed that the plasma concentration-time curve of tinidazole were fitted to an one-compartment model and the main pharmacokinetic parameters of tinidazole have significant differences between male and female volunteers.

关 键 词：替硝唑 高效液相色谱法 药动学 

分 类 号：R969.1[医药卫生—药理学]