丝毛瑞香化学成分研究  

Studies on Chemical Constituents of Daphne holosericea (Diels) Hamaya

作　　者：陈玉琪[1,2] 苏娟[2] 沈云亨[2] 张薇[2] 扈晓佳[3] 许文争[3] 张卫东[2,3] 孔令义[1] 

机构地区：[1]中国药科大学天然药化教研室,南京210009 [2]第二军医大学药学院天然药化教研室,上海200433 [3]上海交通大学药学院,上海200030

出　　处：《中国药学杂志》2008年第19期1453-1456,共4页Chinese Pharmaceutical Journal

摘　　要：目的研究丝毛瑞香的化学成分。方法利用反复硅胶柱色谱、凝胶柱色谱进行分离,通过波谱解析和理化性质进行化合物结构鉴定。结果分离得到10个苯丙素类化合物,分别鉴定为双白瑞香素(1),瑞香新素(2),5′-去甲氧基瑞香新素(3),(-)-双氢芝麻素(4),丁香树脂酚(5),芥子醛(6),edgeworin(7),edgeworthin(8),(-)-epinortrachelogenin(9)和落叶松脂醇(10)。结论化合物9为首次从瑞香科植物中分离所得,其余均为从该植物中首次分离得到。OBJECTIVE To investigate the chemical constituents of Daphne holosericea （Diels） Hamaya. METHODS The separation was obtained by repeated column chromatograph with silica gel and Sephadex LH - 20. The structures were elucidated on the basis of spectral analysis and physical-chemical properties. The spectral data was compared with literature values. RESULTS Ten phenylpropanoids were isolated and identified as daphnoretin （1）, daphneticin （2）, 5＇-demethoxydaphneticin （3）, （ -）- dihydrosesamin （ 4 ）, syringaresinol （ 5 ）, sinapaldehyde （ 6 ）, edgeworin （ 7 ）, edgeworthin （ 8 ）, （ - ） -epinortrachelogenin （ 9 ） and lariciresinol （10）. CONCLUSION Compound 9 was first obtained from the plants of Thymelaeaceae,while the others were isolated from this plant for the first time.

关 键 词：丝毛瑞香 化学成分 苯丙素类 

分 类 号：R282[医药卫生—中药学]