玄参总色素提取物抗炎镇痛活性的研究  

Study on the anti-inflammatory and analgesic effect of pigments from Scrophularia ningpoensis

作　　者：王珲[1] 陈平[1] 张丽萍[2] 肖晏婴[1] 贾红强[1] 马士婧[1] 

机构地区：[1]武汉工业学院生物与制药工程系,湖北武汉430023 [2]湖北中医学院,湖北武汉430065

出　　处：《中国医院药学杂志》2008年第17期1456-1458,共3页Chinese Journal of Hospital Pharmacy

基　　金：湖北省“十五”重大科技攻关项目(编号:2004AA304A)

摘　　要：目的:研究人工栽培玄参中色素提取物的抗炎镇痛作用。方法:采用热板法、冰醋酸刺激致痛法测定小鼠痛阈;利用二甲苯造小鼠耳廓炎症模型,测定小鼠耳片质量;采用腹腔染料渗出法,测定小鼠腹腔毛细血管通透性。结果:玄参色素提取物能提高热板致痛小鼠的痛阈值及减少冰醋酸刺激致痛小鼠的扭体次数;对二甲苯致小鼠耳廓肿胀、冰醋酸致腹腔毛细血管通透性增高均有明显的抑制作用。结论:玄参色素提取物有抗炎镇痛的活性。OBJECTIVE To study the anti-inflammatory and analgesic effect of pigments from Scrophularia ningpoensis Hemsl. METHODS Hot plate law, acetic acid glacial stimulation-induced pain law were adopted to observe the analgesic effect; the xylene induced mouse auricle inflammation model and dye peritoneal exudation model were used to observe the anti-inflammatory effect of pigments from Scrophularia ningpoensis. RESULTS Pigments from Scrophularia ningpoensis Hernsl gavaged in mice significantly prolonged time of pain threshold and significantly reduced writhing times. In addition, the auricle inflammation and the increase of abdominal capillary permeability were significantly inhibited. CONCLUSION It has demonstrated in our study that the pigments of Scrophularia ningpoensis Hemsl has significantly anti-inflammatory and analgesic effect.

关 键 词：玄参 色素提取物 抗炎 镇痛 

分 类 号：R963[医药卫生—微生物与生化药学]