正交试验法优选骨炎宁颗粒的喷雾制粒工艺  

Orthogonal experiments for selecting spraying granulation technique of Guyanning granules

作　　者：吕翼[1] 刘亚妮[1] 陈华庭[1] 黎维勇[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院,湖北武汉430022

出　　处：《中国医院药学杂志》2008年第17期1460-1462,共3页Chinese Journal of Hospital Pharmacy

基　　金：湖北省科技攻关项目(编号:2007AA301C07)

摘　　要：目的:选择骨炎宁颗粒喷雾制粒的最佳工艺条件。方法:应用正交试验法,采用喷雾干燥制粒机制粒并在流化床上进行干燥,以浸膏浓缩的相对比例、进风温度及入塔风压为考察因素,每个因素3个水平,以颗粒的成品率及半成品颗粒的含水量为考察指标。结果:三因素中以浸膏浓缩的相对比例A和入塔风压C的影响较显著(P<0.05),而进风温度B的影响不显著。结论:骨炎宁颗粒喷雾制粒的最佳工艺条件为A3B1C3。即浓缩的相对比例为1:1.20,进风温度为90℃,入塔风压为负压1800Pa。OBJECTIVE To select the optimum conditions for the spray granulation of Guyanning Granules. METHODS The process was studied by orthogonal experimental design, Newly-Fluid-bed-spray-drier-granulation technique was adopted and relative ratio of the extractive, temperature of entry and blast pressure as inspecting factors, three levels of each factors, end-product and the water content of semi-finished Guyanning Granules as inspecting marker. RESULTS extractive and blast pressure was most notable（0. 01〈P〈0. 05）. However, temperature of entry was The relative ratio of the of little importance（P〉0. 05）. CONCLUSION The optimum spraying granulation technique of Guyanning Granules is A3B1C3.

关 键 词：喷雾制粒 颗粒剂 制备工艺 正交试验 

分 类 号：R963[医药卫生—微生物与生化药学]