Different evolutionary lineages of large and small heat shock proteins in eukaryotes  

作　　者：Li-Hua Huang Hong-Sheng Wang Le Kang 

机构地区：[1]State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, B5 Datun Road, Chao Yang District, Beijing 100101, China

出　　处：《Cell Research》2008年第10期1074-1076,共3页细胞研究（英文版）

摘　　要：Dear Editor,Heat shock proteins （Hsps） occur in nearly all organisms , and usually act as molecular chaperones, promoting correct refolding and preventing aggregation of denatured proteins . Based on molecular weight, Hsps can be categorized into several families, including Hsp90, Hsp70, Hsp60, Hsp40 （so-called large Hsps） and small Hsps （sHsps, with the molecular weights varying from 12 to 43 kDa）. Extensive studies have been carried out on the evolution of individual Hsp families, which indicate that the Hsps are organellar proteins . The endosymbiont theory （or gene transfer） is widely accepted to explain the origin of organelle-localized proteins.

关 键 词：真核生物 热休克蛋白 基因转移 进化 

分 类 号：Q51[生物学—生物化学]