腰椎间盘镜手术与常规开窗手术炎性细胞因子动态观察  

Comparative study of serum inflammatory cytokines in lumbar disc herniation patients receiving endoscopic discectomy and conventional discectomy

作　　者：李益中[1] 刘耀明[1] 陈玉梅 

机构地区：[1]兰州军区兰州总医院安宁分院创伤外科,甘肃兰州730070 [2]兰州军区空军机关医院

出　　处：《西北国防医学杂志》2008年第5期342-344,共3页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:比较椎间盘镜手术与常规开窗手术治疗腰椎盘突出症围手术期肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)促炎性细胞因子的变化。方法:正常对照组30例,腰椎间盘突出症患者75例随机分为两组:椎间盘镜组(MED)39例和常规开窗组36例。75例术前1 d、术后1、6、12 d抽取外周静脉血,测定血清中TNF-α、IL-6、IL-8水平并比较。结果:75例术前TNF-α、IL-6、IL-8水平均高于正常对照组;同组手术前后比较:术后6 d,MED组TNF-α、IL-6、IL-8降至术前水平,而常规开窗组仍明显高于术前。结论:椎间盘镜手术治疗腰椎间盘突出症创伤小,炎性反应轻,与术后患者恢复快的临床结果相一致。Objective：To investigate the changes of serum inflammatory cytokines in lumbar disc herniation patients undergoing microendoscopic discectomy and conventional discectomy during perioperative period. Methods： A total of 75 patients with lumbar disc herniation were randomly divided into two groups： group A receiving endoscopic discectomy （n = 39）, and group B receiving conventional discectomy （n = 36）. The control group consisted of 30 healthy adults. ELISA was used to measure the serum TNF - α, IL - 6 and IL - 8 levels. Blood samples were collected from vein ld before operation and 1 d, 6 d, 12 d after operation, respectively. Results： The levels of serum TNF - α, IL - 6 and IL - 8 in 75 cases were significantly higher than those in control group. Six days after operation, the levels of TNF - α, IL - 6 and IL - 8 in group A reduced to the levels before operation, but still maintained the high levels in group B. Conclusion： Endoscopic discectomy is a minimally invasive treatment method with mild inflammatory reaction for patients with lumbar disc herniation, which may possess the advantage of faster recovery after surgery.

关 键 词：腰椎间盘突出症 椎间盘镜手术 肿瘤坏死因子 白细胞介素 

分 类 号：R687.3[医药卫生—骨科学]