盐酸戊乙奎醚门诊手术麻醉前用药临床研究  

Study of Penehyclidine Hydrochloride as Preoperative Medication in Outpatient

作　　者：解轶[1] 黄绍强[1] 

机构地区：[1]复旦大学附属妇产科医院麻醉科,上海200011

出　　处：《药物流行病学杂志》2008年第5期287-289,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:观察盐酸戊乙奎醚用于门诊人工流产手术麻醉前用药的临床疗效、安全性及不良反应。方法:选择240例拟在静脉全麻下行人工流产术的患者,随机分为两组。B组120例,麻醉前静脉注射盐酸戊乙奎醚0.5 mg,A组120例,麻醉前静脉注射阿托品0.25 mg。记录苏醒时间及离院时间,于术后5,15 min,4 h及8 h分别记录镇静镇痛评分、口干程度,观察恶心呕吐。结果:两组患者在苏醒时间、离院时间、术后镇静及恶心呕吐评分上无统计学差异,B组术后15min和4h镇痛评分明显低于A组(P<0.01),4 h口干程度较A组严重(P<0.05),术后8 h组间镇痛评分和口干程度无差异。结论:盐酸戊乙奎醚可安全用于门诊手术麻醉前用药,较阿托品有更好的术后镇痛,但术后口干持续时间长。Objective ： To evaluate the effect and safety of penehyrclidine hydrochloride when it was applied preoperatively in outpatient. Method： 240 patients were randomly divided into two groups. Group P （120 cases） was treated with penehyclidine hydrocbloride 0.5mg before the anesthesia as Group A （120 cases） with Atropine 0.25 mg. Sedation scale was observed just 5 and 15 minutes after drug administration. Analge scale, the degree of the patient＇s dry-mouth and PONV were also recorded. Time of recovery and leaving were studied too. Result： Group P had significantly better analgesic efficacy than Group A（P 〈0.01 ） while the effect of sedation were the same as（P 〉0.05）. The degree of the patients dry-mouth were statistical difference between 2 group both 15min and 4h postoperation（ P 〈 0.01 ）. Other data did not have difference. Conclusion： Penehyclidine hydrochloride used as preoperative medication in outpatient was effective and safe.

关 键 词：盐酸戊乙奎醚 人工流产手术 麻醉前用药 阿托品 

分 类 号：R971.2[医药卫生—药品]