我院2006年甲氨蝶呤血药浓度监测分析  

Monitoring of Serum Concentration of Methotrexate in Our Hospital in 2006

作　　者：杜娆[1] 虞勋[2] 王诚[1] 毛晨梅[1] 盛小英[1] 

机构地区：[1]苏州大学附属儿童医院药剂科,苏州市215003 [2]苏州大学附属第一医院药剂科,苏州市215006

出　　处：《中国药房》2008年第29期2276-2277,共2页China Pharmacy

摘　　要：目的:为临床对急性淋巴细胞性白血病(ALL)患儿化疗方案的顺利实施提供参考。方法:采用荧光偏振免疫法,对我院2006年ALL患儿的甲氨蝶呤血药浓度进行监测、分析。结果:患儿的甲氨蝶呤血药浓度呈现很大的个体差异,达到中毒血药浓度的例数和比例均偏高。结论:在应用高剂量甲氨蝶呤治疗ALL患儿时,应根据血药浓度监测结果及时调整用量,实施合理的个体化治疗方案。OBJECTIVE： To analyze the monitoring results of serum concentration of methotrexate （MTX） to facilitate the chemotherapy for children with acute lymphocytic leukaemia （ALL）. METHODS： Using FPIA to monitor and analyze the serum concentration of MTX in ALL children in our hospital in 2006. RESULTS： There was visible individual difference in the effective dose of MTX in ALL children, and the number and proportion of patients whose blood concentration of MTX reached toxic concentration were on the high side. CONCLUSION： In using MTX for ALL children, the dosage should be adjusted timely based on the monitoring results of the serum concentrations and reasonable individualized treatment is preferable.

关 键 词：急性淋巴细胞性白血病 甲氨蝶呤 血药浓度 

分 类 号：R969.3[医药卫生—药理学] R952[医药卫生—药学]