氨甲苯酸与酚磺乙胺在木糖醇注射液中配伍稳定性考察  

Study on the compatible stability of aminomethylbenzoic acid and etamsylate in 5% xylitol injection

作　　者：徐可嘉[1] 熊建华[1] 章敏[2] 

机构地区：[1]浙江温州市第三人民医院药剂科,温州325000 [2]浙江温州医学院药学院,温州325035

出　　处：《海峡药学》2008年第9期16-17,共2页Strait Pharmaceutical Journal

摘　　要：目的在4℃、25℃和37℃下考察氨甲苯酸与酚磺乙胺在木糖醇注射液中配伍的稳定性。方法采用紫外分光光度法测定氨甲苯酸与酚磺乙胺的含量,同时观察外观变化及测定pH值。结果两药在木糖醇注射液中配伍后,0～8h内其外观、pH值及含量均无明显变化。结论两药配伍后在8h内稳定,可配伍使用。OBJECTIVE To study on the compatible stability of aminomethylbenzoic acid and etamsylate in 5 % xylitol injection at 40C, 25-12 and 370C for 8 hours. METHODS The contents of two drugs were detected by UV-spectrophotometry. The appearance of the solution was observed and its pH value was determined. RESULTS There were no evident variation in content, appearance and pH value after compatibility during 8 hours in 4℃, 25℃, 37℃. CONCLUSION The mixture solution of aminomethylbenzoic acid and etamsylate in 5 % xylitol injection can be used under above mentioned conditions within 8 hours.

关 键 词：氨甲苯酸 酚磺乙胺 木糖醇注射液 稳定性 

分 类 号：R927.11[医药卫生—药学]