PD-ECGF、Survivin在胰腺癌组织中的表达及其与细胞凋亡的关系  

Relationship of platelet-derived endothelial cell growth factor and Survivin expression to apoptosis in pancreatic carcinoma

作　　者：潘峰[1] 任建国[1] 周传文[1] 

机构地区：[1]南京医科大学附属淮安第一医院,江苏淮安223001

出　　处：《山东医药》2008年第34期18-20,共3页Shandong Medical Journal

基　　金：南京医科大学科技发展基金资助项目(NY03056)

摘　　要：目的探讨血小板衍化内皮细胞生长因子(PD-ECGF)和存活素(Survivin)在胰腺癌组织中的表达及其与细胞凋亡的关系。方法应用免疫组化技术检测42例胰腺癌患者癌组织的PD-ECGF和Survivin表达,流式细胞术检测胰腺癌凋亡指数(AI)。结果PD-ECGF的表达与胰腺癌淋巴结转移显著相关,Survivin的表达与胰腺癌组织分化程度显著相关(P均<0.05);两者与AI值均呈显著负相关,两者共同表达阳性者AI值显著低于共同表达阴性者(P均<0.01)。结论胰腺癌组织中PD-ECGF和Survivin可抑制胰腺癌细胞凋亡,促进其增殖与转移。Objective To investigate the relationship of the expression of platelet-derived endothelial cell growth factor（PD-ECGF） and survivin to apoptosis in pancreatic cancer. Methods The expressions of PD-ECGF and Survivin in pancreatic cancer were examined by immunohistoehemical staining in 42 eases , apoptosis index（ AI, percentage of apoptosis cells） in pancreatic cancer was examined by flow cytometry. Results There was a close correction between PD-ECGF expression and lymph node metastasis （ P 〈 0.05 ） , the expression of Survivin was closely related to histological type （ P 〈 0.05 ）. AI in the positive expression of PD-ECGF and Survivin in pancreatic cancer tissues was significantly lower than that in the nagetive expression of PD-ECGF and Survivin（ P 〈 0.01 ）. Combined analysis of PD-ECGF and Survivin showed that tumors with positive expression of both factor had a significantly lower AI than rumors with negative expression of both factor （P 〈 0.01 ）. Conclusions Those findings indicated that the upregulation of PD-ECGF and Survivin might inhibit apoptosis in pancreatic cancer and influence tumor growth and metastasis.

关 键 词：胰腺肿瘤 血小板衍化内皮细胞生长因子 存活素 细胞凋亡 

分 类 号：R753.9[医药卫生—皮肤病学与性病学]