老年良性前列腺增生与体质指数及腰臀比关系  

Body mass index,waist to hip ratio and the risk of benign prostatic hyperplasia in elderly

作　　者：卢智泉[1] 刘玉芳[1] 王立华[2] 贺振权[3] 史玉婷[1] 张国毅[1] 李志强[1] 

机构地区：[1]辽宁医学院预防医学教研室,锦州121001 [2]广东省江门市疾病预防控制中心 [3]辽宁医学院附属第一医院泌尿外科

出　　处：《中国公共卫生》2008年第10期1171-1173,共3页Chinese Journal of Public Health

基　　金：辽宁省教育厅基金项目(991721591)

摘　　要：目的探讨老年男性体质指数（BMI）、腰臀比（WHR）与临床良性前列腺增生（BPH）的关系。方法采取以医院为基础的病例对照研究。病例组为经组织学检查证实为临床BPH的208例男性,对照组为因患其他非前列腺疾病而入住与病例相同医院的同期病人208例。对研究对象在住院期间进行问卷调查,同时对身高、体重、腰围、臀围进行测量。采用多元Logistic回归模型对患者BMI、WHR与临床BPH的比值比（OR）及其95%CI进行统计。结果与正常体型者（WHR〈0.9）相比,向心性肥胖者（WHR≥0.9）发生BPH的危险性增加,OR=1.16,95%CI=1.05-4.87,P〈0.05。在调整了年龄和BMI因素后,与正常体型者相比,无论是超重（BMI 24.0-27.9）或是肥胖（BMI≥28）,发生BPH的危险性均明显增高,超重者OR=2.65,95%CI=1.33-6.96,肥胖者OR=3.00,95%CI=1.81-8.84。结论向心性肥胖是BPH的一个重要危险因素,在超重和肥胖的男性中,向心性肥胖者发生BPH的危脸性明显增高。Objective To explore the association between body mass index （BMI）, waist to hip ratio （WHR） and clinical benign prostatic hyperplasia （BPH） risk in older men. Methods A hospital - based ease - control study was conducted. Cases（ n = 280） were men surgically and histologically confirmed with BPH, and controls （ n = 280） were men admitted to hospital for different diseases not related with prostatic conditions. Using a structured questionnaire, all subjects were interviewed and waist and hip circumference of the subjects were measured. The odds ratios（ OR ） and 95 % confidence intervals （CI） of BPH for BMI and WHR were estimated with unconditional multiple logistic regression models. Results WHR≥0.9 was positively related to BPH （compared with WHR〈 0.9： OR = 1.16, 95 % CI 1.05- 4.87, P 〈 0.05 ）. Age- adjusted relative risks for BPH in WHR≥0.9 versus WHR〈 0.9 stratified by BMI （obesity） were estimated. For men who were overweight （BMI 24.0-27.9） or obesity （BMI≥28.0）, WHR≥0.9 was associated with a significantly increased risk for clinical BPH （compared with WHR〈 0.9： OR = 2.65, 95 % CI 1.33 - 6.96 and OR = 3.00, 95 % CI = 1.81 - 8.84, respectively）. Conclusion Obesity （especially central obesity） is an important risk factor of clinical BPH. For overweight or obesity, central obesity is associated with a significantly increased risk of clinical BPH.

关 键 词：良性前列腺增生 体质指数 腰臀比 病例对照研究 

分 类 号：R558[医药卫生—血液循环系统疾病]