EFFECTS OF ACUPUNCTURE ON THE HYPOTHALAMUS-PITUITARY-OVARY AXIS IN RATS WITH DYSMENORRHEA  

针刺对痛经大鼠下丘脑-垂体-卵巢轴的影响(英文)

作　　者：刘芳[1] 熊瑾[1] 黄光英[1] 王伟[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院中西结合研究所 [2]华中科技大学同济医学院附属同济医院神经内科

出　　处：《World Journal of Acupuncture-Moxibustion》2008年第3期26-35,共10页世界针灸杂志（英文版）

基　　金：National Basic Research Program of China(973 program,No:2006CB504502);Chinese Na-tional Foundation of Natural Sciences.(No.90209009)

摘　　要：Objective To observe the influence of acupuncture on hypothalamus-pituitary-ovary axis （HPOA） in rats with primary dysmenorrhea, and to explore its mechanisms. Methods Effects of acupuncture on the concentration level of β-endorphin （β-EP）, hypothalamic hormone （gonadotropin-releasing hormone, GnRH）, pituitary hormone （GnRH receptor GnRH-R, follicle stimulating hormone FSH, luteinizing hormone LH） and ovarian hormone （estrodiol E2, estrodiol receptor ER, progesterone P and progesterone receptor PR） were observed in dysmenorrheic rats. Results After receiving acupuncture treatment, the levels of 13- EP, GnRH, GnRH-R, FSH, LH, E2, ER, P and PR were changed, and this suggested that acupuncture had a regulative action on HPOA in dysmenorrheic rats. Conclusion The mechanism of acupuncture acting on the HPOA with primary dysmenorrhea might be its regulating role to the gonadal hormone of HPOA and its corresponding receptor expression.目的:观察针刺对痛经大鼠下丘脑-垂体-卵巢轴(HPOA)的影响,并初步探讨其作用机制。方法:观察了针刺对痛经大鼠β-内啡肽(β-EP)、下丘脑激素(促性腺激素释放激素GnRH)、垂体激素(促性腺激素释放激素受体GnRH-R、卵泡刺激素FSH、黄体生成素LH)和卵巢激素(雌激素E2、雌激素受体ER、孕激素P及孕激素受体(PR)的影响。结果:针刺治疗后,β-EP、GnRH、GnRH-R、FSH、LH、E2、ER、P和PR的水平改变,因此针刺对痛经大鼠HPOA的有调节作用。结论:针刺对痛经大鼠HPOA的作用机制可能与针刺调节HPOA的性激素及其受体的表达有关。

关 键 词：Acupuncture Hypothalamus-pituitary-ovary axis Primary dysmenorrhea hormone 

分 类 号：R245[医药卫生—针灸推拿学]