AECOPD与稳定期血清胃动素水平的变化  

The changes of plasma motilin level between acute exacerbation phase and stable phase of chronic obstructive pulmonary disease

作　　者：徐鸥[1] 孙炜[1] 孙士波[1] 何杰明[1] 罗壮[1] 

机构地区：[1]昆明医学院第一附属医院呼吸内科、核医学科,650032

出　　处：《临床肺科杂志》2008年第11期1417-1418,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的观察慢性阻塞性肺病患者(COPD)急性加重期胃肠功能紊乱的因素之一是否与胃动素分泌异常和调节失衡具有相关性。方法采用特异的胃动素抗体,通过放射免疫测定法,测定43例COPD急性加重期与42例稳定期血清胃动素的含量。结果COPD急性加重期组胃动素含量(334±126.5)ng/L较稳定期组(156±38.4)ng/L升高(P<0.01)。且COPD急性加重期组中伴上腹饱胀、嗳气、腹泻等消化道不适者15例胃动素为(391±25.52)ng/L高于28例COPD患者急性加重期无消化道不适者(312±15.21)ng/L(P<0.01)。结论COPD急性加重期胃肠功能紊乱的因素之一与胃动素分泌异常和调节失衡有关。Objective To detect the contents of plasma motilin between acute exacerbation phase and stable phase of chronic obstructive pulmonary disease （COPD） in order to observe the correlation on the factors of gastrointestinal dysfunction and motilin parasecretion and accommodation disequilibrium between acute exacerbation phase and stable phase of COPD. Methods With specific motilin antibody radioimmunoassay, the contents of plasma motilin was determined in 43 patients of COPD in acute exacerbation phase and 42 patients in stable phase. Results The contents of motilin （334 ± 126. 5） ng/L of the acute exacerbation phase of COPD was （P 〈0. 01 ） higher than that in the stable phase （156 ± 38.4） ng/L. For the 15 COPD patients in the acute exacerbation phase who had digestive canal complaints of epigastric repletion, belch and diarrhea, their motilin （391 ± 25.52） ng/L was higher than the 28 patients who without digestive canal complaints （312 ±15.21 ） ng/L （ P 〈 0.01 ）. Conclusion The results show that one of the factors for COPD in the acute exacerbation phase of the gastroenternal functional disorder has bearing on the anomaly of motilin secretion and regulation.

关 键 词：胃动素 慢性阻塞性肺病 放射免疫测定 

分 类 号：R563.9[医药卫生—呼吸系统]