Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure  

作　　者：Li-hong FAN Hong-yan TIAN Ai-qun MA Zhi HU Jian-hua HUO Yong-xiao CAO 

机构地区：[1]Department of Cardiology, The First Affiliated Hospital of Xi-an Jiaotong University School of Medicine, Xi-an 710061, China [2]Department of Pharmacology, Xi 'an Jiaotong University, School of Medicine, Xi-an 710061, China

出　　处：《Acta Pharmacologica Sinica》2008年第10期1167-1174,共8页中国药理学报（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （No 30370677）.Acknowledgement We thank Dr Min LIU for her invaluable help in optimizing the data explanation.Author contribution Ai-qun MA and Hong-yan TIAN designed research; Li- hong FAN performed research; Hong-yan TIAN, Zhi HU, Yong-xiao CAO, and Jian-hua HUO contributed analytic reagents and tools; Hong-yan TIAN and Li-hong FAN analyzed data; Li-hong FAN and Hong-yan TIAN wrote the paper.

摘　　要：Aim： To determine whether ATP-sensitive potassium channels are altered in VSMC from arotas and mesenteric arteries of obese rat, and their association with obesity-triggered increase in blood pressure. Methods： Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats. Control rats were fed with standard laboratory rat chow. Blood pressure and body weight of these rats were measured every 4 weeks. At the end of 24 weeks, KATP channel- mediated relaxation responses in the aortas and mesenteric arteries, KATP channel current, and gene expression were examined, respectively. Results： Blood pressure and body weight were increased in rats fed with high-fat diet. KATP channelmediated relaxation responses, currents, and KATP expression in VSMC of both aortas and mesenteric arteries were inhibited in these rats. Conclusion： Altered ATP-sensitive potassium channels in obese rats may underscore obesity-triggered increase in blood pressure.Aim： To determine whether ATP-sensitive potassium channels are altered in VSMC from arotas and mesenteric arteries of obese rat, and their association with obesity-triggered increase in blood pressure. Methods： Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats. Control rats were fed with standard laboratory rat chow. Blood pressure and body weight of these rats were measured every 4 weeks. At the end of 24 weeks, KATP channel- mediated relaxation responses in the aortas and mesenteric arteries, KATP channel current, and gene expression were examined, respectively. Results： Blood pressure and body weight were increased in rats fed with high-fat diet. KATP channelmediated relaxation responses, currents, and KATP expression in VSMC of both aortas and mesenteric arteries were inhibited in these rats. Conclusion： Altered ATP-sensitive potassium channels in obese rats may underscore obesity-triggered increase in blood pressure.

关 键 词：ATP-sensitive potassium channel obesity- hypertension ELECTROPHYSIOLOGY AORTA mesenteric artery 

分 类 号：R544.1[医药卫生—心血管疾病]