PVA/SA/GT三元复合酸敏凝胶微球的性能研究  

Swelling Characteristic and the Application of Polyvinyl Alcohol/Sodium Alginate/Gelatin Composite Microspheres

作　　者：赵玉强[1] 张琨[1] 张志斌[1] 

机构地区：[1]西南交通大学生物工程学院,成都610031

出　　处：《材料导报（纳米与新材料专辑）》2008年第2期379-381,387,共4页

基　　金：国家自然科学基金资助项目(50573061);四川省应用基础研究项目(07JY029-065);西南交通大学科学研究基金资助项目(2006B52)

摘　　要：采用物理共混法,制备PVA/SA/GT的三元复合凝胶微球,用于盐酸四环素的包载和药物的释放研究。选择5:5:2、5:5:3和5:5:4三种比例制备的微球,研究在模拟胃液和肠液的条件(空白微球对照)下,GT量和pH变化对释药性能和降解性能的影响。结果表明:5:5:4比例相变的微球的释药性能和降解性能都最好;模拟胃液较模拟肠液能加快微球的降解,进而加速微球的释药速率;是否载药对微球的降解性能无影响,但是微球的降解会加速微球的释药速率。In this experiment, using the physical blend method, polyvinyl alcohol （PVA）/sodium alginate （SA）/gelatin（GT） composite microspheres which are used to deliver a model antibiotic drug（tetracycline）is prepared. In this experiment, adopting three kinds of PVA/SA/GT ratios, at the condition of analog gastric juice and analog intestines juice, the influence of the change of GT content and pH on the drug release performance and drug microspheres degradation （as blank microspheres degradation for control） is discussed. The results show that the drug release and degradation performance is the best at the ratio of 5 ： 5 ： 4. Analog gastric juice accelerates the degradation of micro spheres more quickly than analog intestines juice, then accelerates the drug release. Weather loading drug has no effect on microspheres degradation property, but the microspheres＇ degradation can speed the releasing rate of microspheres.

关 键 词：聚乙烯醇 海藻酸钠 明胶 盐酸四环素 缓释 

分 类 号：TB484.3[一般工业技术—包装工程] TQ420.1[化学工程]