肝细胞生长因子及其激活物在子宫内膜异位症的表达  

Expression of HGF and HGF activator in eutopic and ectopic endometrium of patients with endometriosis

作　　者：吴娟子[1] 刘佳[2] 朱桂金[1] 何福仙[3] 

机构地区：[1]华中科技大学同济医学院附属同济医院生殖医学中心,湖北武汉430030 [2]华中科技大学同济医学院附属同济医院肿瘤生物医学中心,湖北武汉430030 [3]华中科技大学同济医学院附属同济医院妇产科,湖北武汉430030

出　　处：《中国妇幼保健》2008年第28期4033-4036,共4页Maternal and Child Health Care of China

摘　　要：目的:探讨肝细胞生长因子(HGF)及其激活物(HGFA)在子宫内膜异位症的表达及与发病机理的关系。方法:采用链霉素抗生物素蛋白-过氧化物酶法检测27例异位内膜、27例对应的在位内膜及25例对照组子宫内膜组织中的HGF和HGFA的免疫表达水平。结果:HGF和HGFA主要在内膜的腺上皮阳性表达,在间质仅弱阳性表达。子宫内膜异位症患者在位内膜腺上皮HGF和HGFA阳性表达最强,异位内膜次之,正常对照组在位内膜腺上皮最弱(P均<0.05)。对照组内膜腺上皮HGF和HGFA的表达增殖期强于分泌期(P<0.05)。HGF和HGFA两者在各组内膜腺上皮中的表达水平呈正相关(P<0.05)。结论:子宫内膜异位症患者在位内膜腺上皮HGF和HGFA的高表达可能与子宫内膜异位症的发病相关。Objective： To investigate the role of hepatocyte growth factor （HGF） and hepatocyte growth factor activator （HGFA） on the pathogenesis of endometriosis. Methods： Ectopic （n = 27） and homologous eutopic endometrium （ n = 27） from women with endo- metriosis and endometrium from women without endometriosis （ n = 25） were included for immunohistoehemical analysis of HGF and HGFA. Results： HGF and HGFA were mainly expressed in glandular cells of eutopic and ectopic endometrium and weakly expressed in stromal cell. Immunohistochemistry revealed increased HGF and HGFA immunoreactivity in eutopic endometrial compared with endometriosis samples in patients with endometriosis and the weakest in endometrium from women without endometriosis （P 〈0.05）. HGF and HGFA endometrial expression levels were significantly higher at the proliferative phase than those of the secretory phase in control women （P 〈0.05） but not in patients with endometriosis. HGF expression was positively correlated to HGFA （ P 〈 0. 05）. Conclusion： Over - expression of HGF and HGFA protein is found in eutopic endometrium of patients with endometriosis. The change of HGF and HGFA expression in eutopic endometrium may be related to the pathogenesis of endometriosis.

关 键 词：子宫内膜异位症 肝细胞生长因子 肝细胞生长因子激活物 

分 类 号：R711[医药卫生—妇产科学]