宫颈HPV亚临床感染与外阴湿疣和宫颈糜烂的相关性  

Ralation of subclinical cervical human papillomavirus infection to vulvar condyloma and cervical erosion

作　　者：曹霞[1] 高娜[2] 黄立 姚嘉斐[4] 

机构地区：[1]中国医科大学附属第四医院,辽宁沈阳110032 [2]大连医科大学附属第一医院 [3]秦皇岛市妇幼保健院 [4]中国医科大学附属第一医院

出　　处：《中国妇幼保健》2008年第29期4152-4155,共4页Maternal and Child Health Care of China

摘　　要：目的:探讨外阴湿疣及宫颈炎症与宫颈HPV亚临床感染(SPI)的关系以及SPI与高危型HPV DNA感染的相关性。方法:对169例研究对象进行基本情况问卷调查,通过宫颈液基细胞检查、阴道镜检查及阴道镜下取组织进行病理诊断,或术后宫颈病理检查,判定有无SPI感染。通过杂交捕获试验Ⅱ检测高危型HPV DNA感染。结果:宫颈SPI的检出率为外阴湿疣组53.1%,宫颈糜烂组为22.7%(P<0.05);97例宫颈糜烂患者中,Ⅰ、Ⅱ、Ⅲ度患者的PSI感染率有逐渐上升趋势,但三者差异无显著性(P>0.05);单纯型、颗粒型、乳头型宫颈糜烂组SPI感染率分别为20.0%、23.4%、22.5%,颗粒型和乳头型糜烂中的SPI感染率略高于单纯型,但三者差异无显著性(P>0.05)。高危HPV DNA的检出率为外阴湿疣组41.7%、宫颈糜烂组为28.7%、正常对照组为8.3%。与正常对照组比较,实验组高危HPV DNA检出率明显提高(P<0.01);宫颈糜烂组与外阴湿疣组比较,高危HPV DNA检出率无统计学意义(P>0.05)。高危型HPV DNA检出率在SPI阳性病例与阴性病例中的检出率分别为69.2%和7.8%,SPI阳性病例与阴性病例比较,高危型HPV DNA检出率明显提高(P<0.01)。结论:外阴湿疣、宫颈炎症患者是宫颈SPI的高危人群,且SPI病例中高危HPV DNA的检出率高于非SPI病例,应重点随访和管理。Objective： To investigate the ralation of subclinical cervical human papillomavirus infection （SPI） to vulvar eondyloma and cervical erosion. Methods： By thinprep cytology, colposeopy, and HC Ⅱ texting for high -risk human papillomavirtrus, 169 women refered to gynecologists with vulvar condyloma, cervical erosion or normal cevix were observed. Results： The rate of findings for cervical SPI in vulvar condyloma, cervical erosion and normal cervix was 53. 1%, 22. 7% and 0%, respectively （P 〈0. 01 and P 〈0. 05）. The rate of findings for cervical SPI in 97 cervical erosion with Ⅰ , Ⅱ , Ⅲand purely, granule, papilla form were respectively 17. 4%, 23. 1%, 27. 3%; 20%, 23. 4%, 22. 5% （P〉0. 05）. The rate of findings for high -risk human papillomavirus DNA in vulvar condyloma, cervical erosion and normal cervix was 41. 7%, 28. 7% and 8. 3% respectively （ P 〈 0. 01 ）. The rate of findings for high - risk HPV DNA in cervical SPI women and non SPI women were respectively 69. 2%, 7. 8% （ P 〈0. 01 ） . Conclusion： Vulvar condyloma and cervical erosion women are the high - risk persons of cervical SPI with high - risk HPV DNA, a high light should be paid on them.

关 键 词：人乳头瘤病毒 亚临床感染 湿疣 宫颈糜烂 

分 类 号：R711.71[医药卫生—妇产科学]