二次脑创伤的基础与临床研究  

A experimental and clinical study on diffuse brain injury with secondary insults

作　　者：费舟[1,2] 章翔[1,2] 易声禹 

机构地区：[1]西安第四军医大学西京医院神经外科 [2]英国爱丁堡大学神经科学研究所

出　　处：《中风与神经疾病杂志》1997年第5期271-273,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：低血压或高热等是引起脑外伤病人二次脑创伤常见因素。本研究首先在大鼠弥漫性脑损伤模型基础上，造成大鼠低血压及高热，观察大鼠脑皮层脑血流（ＣｏＣＢＦ）变化。１６只ＳＤ大鼠随机分为假手术对照、脑损伤并二次脑创伤两组。结果表明，伤后４ｈ与假手术组对比，合并二次脑创伤组ＣｏＣＢＦ显著降低。随后对１６５例重型颅脑损伤病人进行回顾研究，探讨二次脑创伤因素如高热、低血压对颅脑损伤预后的影响。表明合并二次脑创伤因素者预后差。基础与临床研究提示，二次脑创伤者预后差的原因可能是其导致脑血管痉挛，脑血流下降。Hypotention and pyrexia are common secondary insults found in head injured patients.The combination of secondary insults with head injury is associated with increased mortality and morbidity in comparison with head injury alone.In the present study the changes of cortical cerebral blood flow (CoCBF) in Marmaror ,s rodent model of impact acceleration diffuse brain injury with hypotention and pyrexia were observed.16 male SD rats were randomized into sham,injury with insults two groups.All animals were incubated and physiologically monitored minute by minute.The results showed that compared with that of sham group there was a decreased mean CoCBF in head injury with secondary insults group at 4 hours postimpact.Then,a retrospective study on 165 severe head injured patients was made to investigate the effects of secondary insults such as hypotention and pyrexia on the prognosis of primarily injured patients.It shows that patients with secondary insults had a poor outcome.

关 键 词：脑损伤 脑血流 二次脑创伤 

分 类 号：R651.15[医药卫生—外科学]