姜黄素固体分散体的制备及体外溶出特性  

Studies on Preraration of Curcumin Solid Dispersion and its Dissolution Characteristics in Vitro

作　　者：黄秀旺[1] 许建华[1] 吴国华[1] 温彩霞[1] 

机构地区：[1]福建医科大学药学院,福建福州350004

出　　处：《福建中医学院学报》2008年第5期30-33,共4页Journal of Fujian College of Traditional Chinese Medicine

基　　金：福建省重大专项前期研究项目(2005YZ1010)

摘　　要：目的制备姜黄素固体分散体,改善姜黄素的溶出度。方法以泊洛沙姆188为载体,用溶剂熔融法制备固体分散体,以差示扫描量热法、X射线粉末衍射进行物相鉴定,并对所得样品进行体外溶出度研究。结果姜黄素固体分散体中药物部分以分子状态分散,部分以微晶分散,药物的累积溶出速率随载体比例增加而增加,以1∶9的比例效果最好。结论采用泊洛沙姆188制备的固体分散体能显著提高姜黄素的体外溶出度。Objective To prepare the curcumin solid dispersion and improve the dissolution rate of curcumin. Methods Solid dispersions were prepared with poloxamer 188 as carrier by solvent-melting method. The differential scanning calorimeter （DSC） and powder X-ray diffractometry （PXRD） were used to identify the state of the drug existence in the system. The dissolution characteristics in vitro were studied in artificial gastric juice. Results Drug in curcumine solid dispersion partly existed as molecule and partly as fine crystal. The dissolution rates in vitro of all curcumine solid dispersions were larger than the pure drug and showed that higher carrier-curcumine ratio led to faster drug dissolution. Conclusion Dissolution in vitro of eurcumin can been increased significantly by solid dispersions prepared with poloxamer 188 as carriers.

关 键 词：姜黄素 固体分散体 泊洛沙姆188 体外溶出度 

分 类 号：TQ461[化学工程—制药化工]