芪丹益肾降糖胶囊对糖尿病肾病患者T细胞亚群及血液TGF-β IGF-1含量变化的干预研究  

Study of T Lymphocyte Subgroup and Changes of TGF-β IGF-1 in Patients with Diabetic Nephrophthy on Qidan Yishen Jiangtang Capsule

作　　者：贾凤新 李亚秋[1] 李桂[1] 宋春辉[1] 王占平[1] 

机构地区：[1]石家庄平安医院,河北石家庄050021

出　　处：《中华中医药学刊》2008年第10期2201-2203,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省科技支撑计划项目(072761264)

摘　　要：目的:研究芪丹益肾降糖胶囊对糖尿病肾病(DN)患者外周血胰岛素样生长因子(IGF-1)、转化生长因子(TGF-β)、T细胞亚群的影响,并进一步探讨该复方中药抗DN的作用机理。方法:将88例符合入选标准的DN患者,采用双盲双模拟研究方法,随机分为治疗组和对照组,从T细胞亚群(CD3+、CD+4、CD+8、CD4+/CD8+)、TGF-β、IGF-1含量变化等方面进行前瞻性对比治疗研究。结果:DN患者存在免疫功能的低下,血液TGF-β、IGF-1含量明显升高,与健康人比较有显著性差异(P<0.05或P<0.01)。经1个疗程的治疗,两组患者的各观察指标均有不同程度的改善,与治疗前比较有显著性差异(P<0.05及P<0.01);治疗后治疗组与对照组比较,差异有显著性(P<0.05及P<0.01)。结论:芪丹益肾降糖胶囊能明显提高机体的免疫功能,降低DN患者血液TGF-β、IGF-1的含量。说明芪丹益肾降糖胶囊对DN患者的预后影响与提高机体的免疫功能、抑制血液TGF-β、IGF-1的表达有关。Objective ： To explore the effect of T lymphocyte subgroup and changes of TGF-β, IGF - 1 in patients with diabetic nephrophthy on Qidan Yishen Jiangtang capsule, and to better understand the pathogensis of the traditional Chinese medicine formulas . Methods ： 88 cases were taken as observed indexes, double - blind and double - dummy design method was used to observe the therapeutic effects of Chinese drug. 88 cases of pain were randomly divided into treatment group and control group. The patient＇s T lymphocyte subgroup（CD3^＋ ,CD4^＋ ,CD8^＋ ,CD4^＋/CD8^＋ ） ,changes of TGF -β and IGF -1 and so on were retrospectively analyzed. Results： There were increasing level of TGF -β,IGF - 1 and the immunity function was depressed. We found the patients there was significant difference than health personages （P 〈 0. 05 or P 〈0.01 ）. Both of the two groups had improvement in different degree after one period of treatment, and there was significant difference than before treatment and control group （ P 〈 0. 05 or P 〈0.01 ）. Conclusion：Qidan Yishen Jiangtang capsule could obviously decrease contents of TGF -β ,IGF - 1 ,improve the immunity function obviously. The study illuminated that the capsule could improve patients＇ prognosis, which was closely related with decreasing content of TGF-β,IGF - 1 and improving the immunity function.

关 键 词：糖尿病肾病 芪丹益肾降糖胶囊 胰岛素样生长因子 转化生长因子 T细胞 

分 类 号：R259.871[医药卫生—中西医结合]