艾可清胶囊对HIV感染者的疗效观察  

Clinical Effect Analysis of BOTA FOR AID~ Capsule on Prevention and Cure for HIV Cases

作　　者：张苗苗[1] 符林春[1] 蔡卫平[2] 陈谐捷[2] 岑玉文[2] 马伯艳[1] 胡英杰[1] 谭行华[2] 

机构地区：[1]广州中医药大学热带医学研究所,广东广州510405 [2]广州市第八人民医院,广东广州510060

出　　处：《中华中医药学刊》2008年第10期2233-2236,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：广东省科技计划资助项目(2003C33904);广东省中医药管理局资助项目(203105);广州市卫生局科研重点资助项目(2004)

摘　　要：目的:评价中药复方制剂艾可清胶囊延缓HIV感染者发病及缓解相应临床症状体征、改善生存质量的有效性及安全性。方法:36例HIV感染患者口服艾可清胶囊,每次3粒,每日3次,3个月为1个疗程,24例患者完成2个疗程的治疗,其中18例患者完成4个疗程。所有患者分别在治疗前、治疗后3个月、治疗后6个月、治疗后9个月和治疗后12个月检测T细胞亚群、血常规、谷丙转氨酶(ALT)、谷草转氨酶(AST)、肌酐(Cr)、尿素氮(BUN),并记录症状体征积分(积分1)、症状舌脉积分(积分2)、体重,通过Karnovsky Score进行生存质量评价。结果:服用艾可清胶囊6个月、12个月后患者外周血CD4细胞均有所增长,但与治疗前比较无统计学意义;CD4/CD8在治疗6个月时维持稳定状态,治疗12个月后CD4/CD8比值稍有降低;18例患者治疗6个月时积分1与积分2降低明显,患者体重增加明显,Karnovsky Score升高明显,与治疗前相比均具有极显著差异(P<0.01);治疗12个月时患者的两项积分较治疗前也显著降低、体重明显增加、Karnovsky Score明显升高(P<0.01);治疗6个月与治疗12个月相比,积分2降低明显,与治疗前相比差异有显著统计学意义。在连续服用艾可清胶囊12个月后未见肝肾及血常规异常变化。结论:与HIV感染者病情进展一般规律相比,服用艾可清胶囊的患者外周血CD4、CD8细胞计数及CD4/CD8比值保持稳定的前提下有所升高,患者症状、体征、体重、生存质量明显好转,并未见对血常规、肝肾功能的影响,推测艾可清胶囊有延缓HIV感染者发病的作用,并且该项研究为中医药切入艾滋病防治时机的选择提供了新的思路。Objective ：To valuate the effect and safety of BOTA FOR AID （BFA） Capsule by the clinical observation of 24 HIV cases. Method ：24 asymptomatic chronic HIV infected cases were given BFA Capsule which were taken orally ,3 granules,3 times a day. 24 HIV infected patients took B FA Capsule for six months （two treatment courses） and 18 of them took BFA Capsule for one year. All these patients were given CD4^＊ T lymphocyte count test,blood test,liver function test and renal function test and their symptoms and signs were evaluated by the established evaluation criteria including scores of symptoms and signs which is Score 1, and scores of symptoms and tongue and pulse examination which is Score 2 ,and body weight and quality of living by Karnovsky Score before and after 6 and 12 months of treatment. Results ： CD4 counts increased after 6 and 12 months treatment, which had no significant difference compared with pre treatment. CD4/CD8 remained stable. All the 24 cases＇Score 1 and Score 2 decreased evidently and their body weight and Karnovsky Score increased evidently, which had a significant difference between pre treatment with post one and two treatment courses （ P 〈 0.01, P 〈 0.01 ）. However, these indexes had no significant difference between post 2 course treatment and post 4 course treatment. There were no any abnomal changes in blood test and liver and renal function tests of all the 24 cases after 2 and 4 courses. Conclusion ：Compared with the general law of the progression of asymptomatic chronic HIV infection, BFA Capsule not only can improve symptoms and signs and quality of living but also may delay emergency of AIDS. Our study will offer a new thought about the optimal opportunity of Traditional Chinese Medicine in prevention and cure for HIV/AIDS.

关 键 词：艾可清 HIV感染者 临床观察 

分 类 号：R512.9[医药卫生—内科学]