HCV对HBV干扰作用的研究  

Study on the suppressive effect of HCV on HBV

作　　者：何金生[1,2] 沙泉[1,2] 余元勋 毕克菊[1,2] 李瑞珠[1,2] 刘琏 

机构地区：[1]安徽医科大学微生物学教研室 [2]安徽省优生优育遗传医学中心

出　　处：《安徽医科大学学报》1997年第5期530-531,共2页Acta Universitatis Medicinalis Anhui

基　　金：安徽省教委资助

摘　　要：应用ＰＣＲ及ＥＬＩＳＡ技术，分析ＨＣＶＲＮＡ阳性及阴性标本的ＨＢＶＤＮＡ及ＨＢｓＡｇ的感染状况，以探讨ＨＣＶ对ＨＢＶ的干扰作用。结果发现当ＨＢｓＡｇ阳性时，无论ＨＣＶＲＮＡ是否阳性，ＨＢＶＤＮＡ的阳性率分别为５３．８５％和５９．０９％，无明显差异，（Ｐ＞０．０５）；当ＨＢＶＤＮＡ阳性时，两组ＨＢｓＡｇ的转阴率分别为３３．３３％和２３．５３％，无明显差异，（Ｐ＞０．０５）。实验表明ＨＣＶ对ＨＢＶ复制无抑制作用。In order to investigate the suppressive effect of HCV on HBV, HBV DNA and HBsAg of positive and negative HCV RNA sera were tested by PCR and ELISA. Whether HCV RNA was positive or not. The data showed no difference between the positive percentage of HBV DNA with positive HBsAg (53 85% and 59 09%) and the negative percentage of HBsAg with positive HBV DNA (33 33% and 23 53%), respectively ( P> 0 05). The results suggested that these was no suppressive effect of HCV on HBV replication.

关 键 词：乙型炎病毒 甲型肝炎病毒 病毒复制 

分 类 号：R373.21[医药卫生—病原生物学]