β-七叶皂甙钠预防急性放射性肺损伤临床疗效观察  

The Prevent Effect of β-Escin Natrium on Acute Radiationinduced Pulmonary Injury

作　　者：袁秀文[1] 翟贵山 叶景郁 杜志刚[2] 王艳玲[2] 

机构地区：[1]河北省唐山市第三医院呼吸内科,063000 [2]华北煤炭医学院附属医院神经内科,063000

出　　处：《中国保健营养（临床医学学刊）》2008年第6期16-18,共3页China Health Care Nutrtion

摘　　要：目的观察β-七叶皂甙钠预防急性放射性肺损伤临床疗效。方法将64例放疗肺癌患者随机分为二组：单纯放疗对照组（RT）和放疗加用β-七叶皂甙钠观察组（RT＋Q）。根据RTOG诊断标准将放射性肺损伤分为0—4级，以≥2级者为观察指标，同时观察肺功能、影像学变化；并比较二组KPS评分。结果急性放射性肺损伤总发生率观察组15．63％，对照组46．88％；观察组肺功能明显改善，KPS评分优于对照组（P〈0．01），未出现不良反应。结论β-七叶皂甙钠能有效预防严重急性放射性肺损伤的发生，无激素类药物不良反应；可提高患者生活质量。Objective： To observe the Prevent Effect of β-Escin Natrium on Acute Radiationinduced Pulmonary Injury. Methods： Selected Patients of lung cancer （n=64） were divided into two groups. A control group was treated by radiotherapy （RT） and an observed group was treated by β-Escin Natrium with radiotherapy （RT＋Q）, starting on the first day of radiotherapy. Acute Radiotherapy Pulmonary injury were graded from 0 to 4 according to RTOG . ≥ Grade 2 pneumonitis were diagnosed, lung function and imageology＇ s change were observed; All patients were compared the KPS＇ s score and over above of two groups after 6 month. Results： The patients were evaluated, the rate of Acute Radiationinduced pneumonitis： 15. 63% in the RT＋Q group and 46. 88% in the RT group. lung function and KPS＇ s score were improved in RT＋Q group than RT group （P〈0. 01）, without the side effect. Conclusion： It is obverse that β-Escin Natrium can Prevent the Acute Radiationinduced Pulmonary Injury and improve the quality of life in patients.

关 键 词：Β-七叶皂甙钠 预防 急性放射性肺损伤 

分 类 号：R917[医药卫生—药物分析学]