L-荷包牡丹碱对实验性急性心肌缺血缺氧性损伤的保护作用  

Protective Effect of L Dicentrine on Acute Myocardial Ischemia and Anoxia Lesion

作　　者：李牧[1,2] 苏善国[1,2] 苏彦宏[1,2] 李惠兰[1,2] 

机构地区：[1]昆明医学院药理教研室 [2]昆明医学院第一附属医院心电图室

出　　处：《昆明医学院学报》1997年第3期63-64,69,共3页Journal of Kunming Medical College

摘　　要：静脉注射脑垂体后叶素（ＰＰＨ）诱发３０只豚鼠急性心肌缺血及夹闭小鼠气管后引起心肌缺氧，结果：实验组及阳性对照组与对照组比较，各项指标Ｐ值均＜０．０１．结果提示：Ｌ－荷包牡丹碱１０ｍｇ／ｋｇｉｖ和２５ｍｇ／ｋｇｉｐ有较强的抗心肌缺血缺氧效应．Posterior pituitary hormone (PPH) was intravenously injected in quinea pigs to evoke acute myocardial ischemia and mouse trachea was clipped to induce anoxia lesion. Result: P value was less than 0 01 for each index when comparisons were made among experiment group, positive group and control group. Implication: With a dosage of 10 mg/kg iv and 25 mg/kg ip, L dicentrine had a strong effect on acute myocardial ischemia and anoxia.

关 键 词：心肌缺血 缺氧 脑垂体后叶素 L-荷包牡丹碱 

分 类 号：R654.2[医药卫生—外科学] R965[医药卫生—临床医学]