单纯夜间高血压与左室肥厚的关系  

The relationship between isolated nocturnal hypertension and left ventricular hypertrophy

作　　者：陆璐[1] 李燕[1] 黄绮芳[1] 李利华[1] 盛长生[1] 王继光[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院上海市高血压研究所,200025

出　　处：《中华内科杂志》2008年第10期819-822,共4页Chinese Journal of Internal Medicine

基　　金：国家自然科学基金（30571607）;上海市科委基础研究重点项目（07JC14047）

摘　　要：目的探讨单纯夜间高血压与左室肥厚的关系。方法在浙江省景宁县14个村的居民中，记录24h血压和12导联心电图。结果647例受检者中单纯夜间高血压[平均血压≥120／70mmHg（1mmHg=0．133kPa）]有72例（11．1％）。夜州和白天的收缩压或舒张压都是左室肥厚的独立影响因素（P〈0．01）。但单纯夜间高血压患者左室肥厚的患病率（23．6％）与正常血压者（17．4％）相比，差异无统计学意义（P=0．24）。结论在本横断面研究中，单纯夜间高血压与用心电图诊断的左室肥厚没有显著独立关联。Objective To investigate the relationship between isolated nocturnal hypertension and left ventricular hypertrophy. Methods In the inhabitants of 14 villages in Jingning County, Zhejiang Province, we performed 24-hour ambulatory blood pressure monitoring with SpaceLab monitors and measured 12-lead resting electrocardiogram using an electronic recording system of GE company. Left ventricular hypertrophy was diagnosed with the criteria of Sokolow-Lyon voltage amplitude and Cornell product. Isolated nocturnal hypertension was defined as a nighttime （from 22：00 to 4：00） blood pressure of ≥ 120/70 mm Hg （ 1 mm Hg = 0. 133 kPa）. Isolated daytime （from 8 ：00 to 18：00） hypertension was a diurnal blood pressure of ≥ 135/85 mm Hg. When both conditions were present or absent, subjects were classified either as having combined day-night hypertension or as normotensive on ambulatory measurement. Analysis of variance and multiple regressions were used for statistical analysis. Results 647 participants （53. 9% being female, average age 47. 8 years） included 72 patients with isolated nocturnal hypertension, 33 with isolated daytime hypertension and 248 with day-night sustained hypertension. Compared with normotensive subjects, patients with isolated nocturnal hypertension and day-night sustained hypertension had a higher Sokolow-Lyon voltage amplitude and Cornell product. However, after adjustment for sex, age, body mass index, drinking and smoking habits, serum total cholesterol, fasting blood glucose and the use of antihypertensive drugs, only day-night hypertensive patients had a significantly higher Sokolow-Lyon voltage （ 32.8 mV, P = 0. 0003 ） and Cornell product （ 1371 mV ×ms, P = 0. 0004） than normotensive subjects （29.0 mV, 1114 mV ×ms）. Regardless of whether Sokolow-Lyon or Cornell criteria were used, both nighttime and daytime systolic and diastolic blood pressure were independent risk factors of left ventricular hypertrophy （P 〈 0. 01 ）. However, the prevalence of left v

关 键 词：高血压 心肌疾病 心电描记术 

分 类 号：R686[医药卫生—骨科学]