寿聪胶囊对老年痴呆模型大鼠行为学及过氧化氢酶、单胺氧化酶的影响  

Effect of Shoucong Capsule on Learning-memorial Ability and CAT,MAO Activities in Alzheimer Disease Rats

作　　者：李满生 徐厚谦[2] 金华[2] 邓兴本[2] 牛彩琴[2] 颜春鲁[2] 杨维杰[2] 

机构地区：[1]平顶山市第二人民医院,河南平顶山467000 [2]甘肃中医学院,甘肃兰州730000

出　　处：《中国中医药信息杂志》2008年第10期34-35,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：甘肃省科技厅立项研究课题(QS012-C33-25)

摘　　要：目的观察寿聪胶囊对老年性痴呆(Alzheimer disease,AD)模型大鼠行为学及脑组织中过氧化氢酶(CAT)、单胺氧化酶(MAO)活性的影响,探讨其作用机制。方法选用Wistar雄性大鼠,随机分成空白对照组、模型对照组、脑复康组及寿聪胶囊低、高剂量组,每组9只。大鼠颈部注射D-半乳糖合并腹腔注射东莨菪碱制备AD大鼠复合模型,采用跳台法观察大鼠学习记忆能力,用分光光度法测定脑组织中CAT、MAO的含量。结果寿聪胶囊能显著减少AD大鼠的错误次数、延长反应潜伏期,能显著提高模型大鼠脑组织中CAT的含量、降低MAO的含量。结论寿聪胶囊可能通过提高CAT抗氧自由基水平及降低脑组织MAO活性的途径实现其对AD模型大鼠预防和治疗作用。Objective To study effects of Shoucong capsule on the learning-memorial ability, CAT and MAO activities in brain tissue of AD rat. Methods Male Wistar rats were randomly divided into 5 group： blank compared group, model compared group, Naofukang group and Shoucong capsule （low, high dose） group, every group contained 9 rats. They were injected with D-galactose into the neck and injected with scopolamine into the intraperiton to making AD compound model rats. The learning-memorial ability were examined by diving-stand test, and CAT and MAO activities in brain tissue were determined by spectrophotometry. Results Shoucong capsule greatly deceased error time and enhanced the electric latent period, and enhanced the activities of CAT while deceased the activities of MAO in model rats. Conclusions Shoucong capsule has significantly effect of preventing and treating senile dementia in AD rats by enhancing the activities of CAT and deceasing the activities of MAO in brain tissue.

关 键 词：寿聪胶囊 阿尔茨海默病 学习记忆能力 过氧化氢酶 单胺氧化酶 大鼠 

分 类 号：R285.5[医药卫生—中药学]