利福平胸腔注入治疗结核性胸膜炎的疗效分析  

Analysis on the Clinical Effect of Rifampicin Injected into Pleural Cavity on Tuberculous Pleurisy

作　　者：冯光明[1] 王立兵[1] 

机构地区：[1]河南省安阳市结核病防治所,455000

出　　处：《职业与健康》2008年第21期2357-2358,共2页Occupation and Health

摘　　要：目的观察胸腔内注入利福平、异烟肼和地塞米松治疗结核性胸腔积液的疗效。方法将安阳市结核病防治所收治的初治中等量结核性胸腔积液患者98例,随机分为观察组48例和对照组50例,2组除均按照同样的抗结核方案治疗外。观察组抽胸腔积液后注入利福平、异烟肼和地塞米松,对照组抽胸腔积液以后只注入异烟肼和地塞米松,比较2组的疗效。结果治疗胸膜炎疗效观察组好于对照组(χ2=25.52,v=2,P<0.01)。主要表现在观察组胸腔穿刺次数较对照组减少,胸腔积液完全吸收时间较对照组显著变短,胸膜增厚、粘连与对照组比较其差异有统计学意义(χ2=12.02,P<0.01),临床症状与对照组比较其差异有统计学意义(χ2=6.94,P<0.01)。结论胸腔内注入利福平、异烟肼和地塞米松治疗结核性胸腔积液优于常规胸腔内只注入异烟肼和地塞米松的疗效。[ Objective] To observe the clinical effect of injecting rifampicin, isoniazid and dexamethasone into pleural cavity on tu- berculous pleurisy. [ Methods]98 cases of initial treatment with middle of tuberculous pleural effusion were randomly divided into two groups which were treated by the same antituberculous programme. After pumping pleural effusion, treatment group （48 cases } received rifampicin, isoniazid and dexamethasone injected into pleural cavity, control group （50 cases ） only received isoniazid and dexametbasone injected. The effects between the two groups were compared. [ Results ] Compared with control group, the pleural puncturing frequency of treatment group was less （ P 〈 0.01 ） , the time of pleural effusion completely absorbed was significantly shorter（ P 〈 0.01）. There were significant differences in the pleural incrassation, pleural conglutination,and clinical symptoms between the two groups （ P 〈 0.01）. [ Conclusion] Compared with only conventionally injecting isoniazid and dexamethasone into pleural cavity,the clinical effect of injecting rifampicin,isoniazid and dexamethasone on tuberculous pleurisy was much more better.

关 键 词：利福平 异烟肼 地塞米松 胸腔积液 

分 类 号：R521.7[医药卫生—内科学]