头电针治疗血管性痴呆的临床多中心随机对照研究  

RCT Research on Scalp electric Acupuncture Improving Cognition Function of VascuLar Dementia Patients

作　　者：张虹[1] 赵凌[1] 刘军[2] 何成奇[3] 胡卡明[4] 

机构地区：[1]成都中医药大学针灸推拿学院,四川成都610075 [2]成都市中西医结合医院,四川成都610061 [3]四川大学华西医院,四川成都610041 [4]成都中医药大学附属医院,四川成都610072

出　　处：《成都中医药大学学报》2008年第3期9-12,共4页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家中医管理局资助项目(任务编号:02-04LP45)

摘　　要：目的:采用多中心随机对照试验的方法,研究头电针对血管性痴呆(VD)患者认知功能的改善,为针灸临床提供可靠证据。方法:将纳入试验的270例患者随机分配到针药组、电针组和针药结合组,共治疗6周。治疗前后分别进行MMSE量表和P300的检测。结果:3个试验中心完成良好,具有可比性。血管性痴呆患者治疗后在MMSE量表评分和P300检测中均显示:电针组和针药组较药物组均有极显著性差异(P<0.01),且针药组和电针组相比有显著性差异(P<0.05)。结论:头电针配合口服尼莫地平对改善VD患者认知功能和日常生活能力较单独采用电针或单纯口服尼莫地平疗效好,且安全性高。头电针配合尼莫地平能够明显改善VD患者的认知功能和判断功能,提高大脑皮层的兴奋性。Objective： To investigate the clinical effect of scalp electric acupuncture on vascuLar dementia, and apply the evidence for clinic. Methods： 270 patients were involved in this trial, and divided into 3 groups. Every group measured MMSE measuring scale, and P300 test before treatment, and then rechecked 6 weeks later when treatment course were completed. ResuLt： This trial was well completed and the characteristics of 3 clinic centers were comparable. After treatment, both of the scalp electric acupuncture group and scalp electric acupuncture with Nimodipine group has extreme significant difference with Nimodipine group, and scalp electric acupuncture with Nimodipine group has significant difference with electro - acupuncture group. Conclusion： scalp electric acupuncture with Nimodipine has the best effect and high safe. This method can improve patients＇ abilities about recognition and decision obviously, and can elevate excitability about cerebral cortex.

关 键 词：电针 血管性痴呆 MMSE量表 ADL-R量表 P300 

分 类 号：R246.6[医药卫生—针灸推拿学] R749.1[医药卫生—中医临床基础]