波棱瓜子提取物对四氯化碳所致小鼠急性肝损伤的保护作用  

Protective Effect of Herpetospermum Caudigerum Extracts on Liver Injury Induced by Carbon Tetrachloride in Mice

作　　者：陈兴[1] 张梅[1] 汤沛然[1] 赵波[1] 

机构地区：[1]成都中医药大学药学院,四川成都610075

出　　处：《成都中医药大学学报》2008年第3期45-46,共2页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：四川省教育厅资助科研项目(NO2006A040)

摘　　要：目的:研究波棱瓜子乙酸乙酯提取物对四氯化碳所致小鼠急性肝损伤的保护作用。方法:建立四氯化碳(CC l4)诱导小鼠肝损伤模型,以测定血清谷丙转氨酶(ALT)、谷草转氨酶(AST)和肝组织丙二醛(MDA)含量为指标来观察波棱瓜子乙酸乙酯提取物对四氯化碳所致小鼠急性肝损伤的保护作用。结果:波棱瓜子乙酸乙酯提取物高中低剂量组均能不同程度的降低动物模型的血清ALT、AST和肝脏MDA的含量。结论:波棱瓜子乙酸乙酯提取物对化学性肝损伤具有明显的保护作用。Objective： To study the protective effect of the ethyl acetate extracts of Herpetospermum eaudigerum on liver injury induced by carbon tetrachloride （CC14 ） in mice. Methods： Mice were administracted with different concentrations of the ethyl acetate extracts for 7 days, and then acute liver injury model was induced by 0. 1% carbon tetrachloride ip 10 mL/kg. The mice were killed 16 hours after ip of the CCI4. serum ala - nine and aspartate aminotransferase （ ALT and AST） activity were measured, and maleic dialdehyde （MDA） activity in liver were detected. ResuLts： Different concentrations of the ethyl acetate fraction significantly decreased the activities of serum ALT and AST and the content of MDA. Conclusion： the ethyl acetate extracts of H. caudigerum showed protective effects on acute liver injury induced by CC14 in mice.

关 键 词：波棱瓜子 四氯化碳(CCl4) 肝损伤 

分 类 号：R285.5[医药卫生—中药学]