均匀设计法优选川芎提取物的提取工艺研究  

Optimization of Process of the Rhizoma Chuanxiong Extract by the Uniform Design

作　　者：向永臣[1] 赖先荣[1] 张婧[1] 

机构地区：[1]成都中医药大学,四川成都610075

出　　处：《成都中医药大学学报》2008年第3期62-64,共3页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：成都中医药大学校基金重点项目(项目编号:ZRZD200504)的资助

摘　　要：目的:筛选优化川芎提取物的提取工艺。方法:采用均匀设计法,以提取物收率和总内酯含量为指标,对川芎提取物的提取工艺进行优选。结果:最佳提取工艺条件为:采用渗漉法,粉碎粒度为20目,以90%的乙醇为溶剂,用量为6倍量,浸泡时间为24 h,渗漉速度为2 mL/min。验证试验结果表明提取物收率为7.36%,总内酯含量为3.55%。结论:建立的川芎提取物的提取工艺稳定、可行,适合放大生产。Objective： To find out the optimum parameters of the Chuanxiung extract. Method： Used the uniform design method, investigated the effects of the ratio of extraction and the content of total lactones. Result： The optimum condition was obtained： introduced the diacolation, added six folds of ethanol at 90 percent concentration, twenty four hours in duration for infusion time. Results of duplicate test： the ratio of extraction was 7.36%, the content of total lactones was 3.55%. Conclusion： The extraction process shows stabilization and feasibility, can be available for industrial production at large scale.

关 键 词：川芎 提取工艺 渗漉法 均匀设计 

分 类 号：R284.2[医药卫生—中药学]