慢性乙型肝炎患者LAK细胞治疗前后T淋巴细胞亚群的变化  

CHANGES OF T LYMPHOCYTE SUBSETS IN CHRONIC HEPATITIS B PATIENTS BEFORE AND AFTER LAK CELLS TREATMENT

作　　者：罗光汉[1] 周桂英[1] 吴继周[1] 江建宁[1] 玉艳红[1] 

机构地区：[1]广西医科大学第一附属医院传染病科

出　　处：《广西医科大学学报》1997年第2期23-25,共3页Journal of Guangxi Medical University

摘　　要：观察４０例慢乙肝用异体淋巴因子激活的杀伤细胞（ＬＡＫ细胞）治疗前后外周血Ｔ淋巴细胞亚群的变化，并与肝病对照组、正常对照组比较。结果发现慢乙肝患者ＣＤ＋３、ＣＤ＋４、ＣＤ＋８及ＣＤ＋４／ＣＤ＋８比值均明显低于正常对照组（Ｐ＜０．０５）。用ＬＡＫ细胞治疗后，观察组ＣＤ＋３、ＣＤ＋４和ＣＤ＋４／ＣＤ＋８比值比治疗前上升（Ｐ＜０．０５），接近正常对照组，ＣＤ＋４／ＣＤ＋８比值升高与ＣＤ＋４升高有关。ＣＤ＋８治疗前后均低于正常对照组。结果提示输ＬＡＫ细胞后，由于ＣＤ＋４细胞的增加，对机体免疫调节网络具有启动调节和促进作用。Changes of T lymphocyte subsets in patients with chronic hepatitis B treated by allologous LAK cells was observed and compared with those of chronic hepatitis B controls and normal controls The results showed that CD + 3,CD + 4,CD + 8 and CD + 4/CD + 8 ratio in the pretreated chronic hepatitis B patients decreased significantly (P<0 05) as compared with the normal controls The CD + 3,CD + 4 and CD + 4/CD + 8 ratio in the LAK cells treated patients increased significantly and were almost the same as those of the normal controls The increase in CD + 4/CD + 8 ratio was related to the increase of CD + 4 However,the valucs of CD + 8 before and after treatment were lower than those of the normal controls This study suggests that the increased in CD + 4 by the transfusion of LAK cells plays an important role in the regulation and enhancement of the immuno networks of the body

关 键 词：LAK细胞 T细胞亚群 乙型肝炎 慢性 

分 类 号：R512.62[医药卫生—内科学]