白藜芦醇干预对耐力训练小鼠腹腔巨噬细胞吞噬功能、血清IL-2、sIL-2R和IgG浓度的影响  

Effects of Resveratrol Treatment on the Phagocyte Capacity of Peritoneal Macrophage,IL-2,sIL-2R and IgG Concentration in Serum of Mice Performing Endurance Exercise

作　　者：刘艳[1] 文质君[1] 陈筱春[1] 黄元汛[2] 叶敏珊[1] 

机构地区：[1]广东湛江师范学院,广东湛江524048 [2]湖北大学体育学院,湖北武汉430062

出　　处：《首都体育学院学报》2008年第4期68-71,共4页Journal of Capital University of Physical Education and Sports

摘　　要：为了研究白藜芦醇干预对耐力训练小鼠腹腔巨噬细胞吞噬功能、血清IL-2、sIL-2R和IgG浓度的影响。根据体重将72只昆明雄性小鼠随机分为三组:A组为安静对照组;B组为耐力训练组;C组为耐力训练+白藜芦醇组。C组小鼠每日给予白藜芦醇10mg/kg灌胃,与B组共同进行6周递增负荷游泳训练,最后一天进行力竭游泳实验并记录运动时间。力竭后24 h处死小鼠取材,测定各组小鼠腹腔巨噬细胞吞噬率和吞噬指数,血清IL-2、sIL-2R和IgG浓度。结果发现:白藜芦醇显著提高耐力训练小鼠力竭游泳时间(P<0.05);6周耐力训练使小鼠腹腔巨噬细胞吞噬率和吞噬指数显著低于安静对照组(P<0.05),白藜芦醇显著提高耐力训练小鼠腹腔巨噬细胞吞噬率和吞噬指数(P<0.05);6周耐力训练对小鼠血清IL-2、sIL-2R和IgG浓度均无显著影响(P>0.05),而白藜芦醇显著提高耐力训练小鼠血清IL-2和IgG浓度(P<0.05)。得出结论:6周大强度耐力训练使小鼠腹腔巨噬细胞吞噬能力显著降低,但对小鼠血清IL-2、sIL-2R和IgG浓度等免疫指标无显著影响。白藜芦醇干预提高了耐力训练小鼠腹腔巨噬细胞吞噬功能、血清IL-2和IgG的浓度。提示白藜芦醇可能是通过提高耐力训练小鼠的细胞免疫功能而提高其运动能力的。Objectives：The purpose of this study is to investigate the effects of resveratrol treatment on the phagocyte capacity of peritoneal macrophage, IL-2, sIL-2R and IgG concentration in serum of mice performing endurance exercise. Methods： 72 Kunming male mice were randomly divided into 3 groups according to weight：group A （Sedentary Control） ,group B （Endurance exercise） and group C （Resveratrol ＋ Endurance exercise）. Administrated of resveratrol with 10 mg kg-ld-l,the mice of group C were given incre- mental load protocol of swimming for six weeks,and then an exhaustion swimming as did the mice of group B. All mice were sacrificed and sampled after the last 24 hours＇ swimming test and record of time used. The following parameters in mice were tested：phagocytic indexes and phagocytic rate of peritoneal macrophage, IL-2,sIL-2R and IgG concen- tration in sermn of mice. Results：ResveratroI treatment has significantly extended swim- ming time to exhausted in mice performing endurance exercise（P〈0.05）. The phagocytic indexes and phagocytic rate of peritoneal macrophage in training mice has significantly decreased compared with sedentary control group after 6 weeks training （P〈0. 05）, while resveratrol treatment resulted in significant increase in phagocytic indexes and phagocytic rate of peritoneal macrophage of mice performing endurance exercise （P〈 0.05）. Conclusion： Six weeks＇ endurance exercise had no effects on IL-2, sIL-2R and IgG concentration in serum of mice, whereas resveratrol treatment improved phagocytic capacity of peritoneal macrophage, enhanced IL-72 and IgG concentration in serum of mice performing endurance. It was suggested that reseveratrol treatment has enhanced the immunity capacity, and thus benefited the athletic performance of mice performing endurance exercise.

关 键 词：白藜芦醇 腹腔巨噬细胞吞噬功能 IL-2 SIL-2R IGG 耐力训练 

分 类 号：G804.7[文化科学—运动人体科学]