脂糖舒对D-半乳糖衰老模型小鼠器官指数和自由基代谢的影响  

Effects of Zhitangshu on Organic Indexes and Free Radical Metabolism in Aged Model Mice Induced by D-galactose

作　　者：吴丹[1] 舒慧[2] 舒思洁[2] 吴基良[2] 汪晖[3] 

机构地区：[1]武汉大学在读硕士,湖北武汉430071 [2]咸宁学院药学院药理学教研室 [3]武汉大学基础医学院药理学系

出　　处：《咸宁学院学报（医学版）》2008年第4期288-289,293,共3页Journal of Xianning Univarsity(medical Sciences)

摘　　要：目的观察脂糖舒对D-半乳糖衰老模型小鼠器官指数和自由基代谢的影响。方法采用D-半乳糖制备小鼠衰老模型,同时灌胃不同剂量脂糖舒(Ⅰ组5g/kg、Ⅱ组10g/kg),1次/d、连续6周,并取健康小鼠10只作正常对照。6周末检测各组小鼠的器官指数和血浆中超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量。结果模型组小鼠除心肌外,肝、脑、肾等器官指数明显降低,血浆SOD活性显著降低,MDA含量显著升高(较正常组P<0.05或0.01);而脂糖舒二剂量组均能够提高小鼠的脑指数和肾指数,提高血浆SOD活性,降低MDA含量(较模型组P<0.05或0.01),但脂糖舒二剂量组间心、肝、脑、肾指数及血浆MDA含量无显著差异(P>0.05),而血浆SOD活性差异显著(P<0.01)。结论脂糖舒具有一定的延缓衰老作用。Objective To observe the effects of Zhitangshu（ZTS） on the organic indexes and free radical metabolism in aged model mice.Methods The aged model of mice was made by D-galactose,then they were treated intragastrically with different doses of ZTS（Ⅰgroup：5g·kg^-1·d^-1,Ⅱgroup：10g·kg^-1·d^-1）for six weeks with other ten mice as control.At the end of the sixth week,the organic indexes,activity of superoxidase（SOD） and the content of malondialdehyde（MDA） in plasma of mice were mesaured.Results Compared with control group,excepting heart index,the organic indexes of liver,brain and kidney was decreased（P〈0.05）,the activity of SOD was reduced and the content of MDA in plasma was increased in aged model group（P〈0.01）.Compared with model group,the organic indexes of brain and kidney and the activity of SOD in plasma were increased and the content of MDA in plasma was significantly decreased in low and high doses of ZTS groups（P 〈0.05 or P 〈0.01）.Conclusion ZTS has the effect of delaying senility.

关 键 词：脂糖舒 D-半乳糖 器官指数 自由基 小鼠 

分 类 号：R965.1[医药卫生—药理学]