猪切口疝模型的建立及使用生物型补片修补的研究  

Empirical study of establishing piglet model of incisional hernia and repairing the hernia with biotic patch

作　　者：邓美海[1] 林楠[1] 胡昆鹏[1] 钟跃思[1] 胡啷[1] 徐国风 黄慧妍 

机构地区：[1]中山大学附属第三医院普外科,广州510630 [2]广东冠吴生物科技有限公司

出　　处：《中华实验外科杂志》2008年第10期1260-1261,共2页Chinese Journal of Experimental Surgery

基　　金：广东省科技计划资助项目（2006860501007）

摘　　要：目的建立小猪切口疝模型并探讨生物型疝补片在切口疝修补治疗中应用的可行性。方法通过在小猪上腹部制作一个肌肉筋膜层缺损区的方法建立切口疝模型，分别采用二期修补和一期修补的方式，使用生物型补片无张力修补切口疝。观察术后切口感染、疝复发等并发症及补片组织的病理学变化。结果术后1周时可获得典型的切口疝模型；一期修补组未发生切口疝，二期修补组6只小猪成功，2只因切口感染、补片排出而失败。术后6个月内观察，生物补片的胶原变性吸收，逐渐被结缔组织所替代，大体上逐渐形成一致密结缔组织层并自体腱膜化。结论本研究所采用的切口疝模型制作方法成功率高、可重复性好。用生物型疝补片修补小猪切口疝可行，并预示着此生物补片可能是一种较为理想的腹外疝修补材料。Objective To establish a piglet model of incisional hernia and explore the feasibility of repairing the hernia with biotic patch. Methods The model of incisional hernia was established by the defect of abdominal muscle and fascia made on the epigastric zone of piglet. The incisional hernias were re- paired with biotic patch tension-free in the one-stage operation and second-stage operation respectively. The complication of infection of incisional wound and recurrence of hernia, pathological change of the patch were investigated. Results The model of incisional hernia was established one week postoperatively and typically. There was not occurrence of incisional hernia in the one-stage operation group and the incisional hernias were repaired successfully in 6 piglets of the second-stage operation group ,but two piglets＇ repair operations failed because of infection of incisional wound and discharging of the patch. The collogen of the biotic patch deformed and was absorbed and replacect by connective tissue gradually, then the patch turned to be dense connective tissue and tendinous membrane by the assimilation of piglet. Conclusion The model of incisional hernia established in this study is successful and of good repeatability. It is feasible to repair the incisional hernia of piglet with biotic patch, and the biotic patch could be an ideal patch for repairing abdominal external hernia.

关 键 词：生物补片 模型 动物 疝修补术 病理学 

分 类 号：R656.2[医药卫生—外科学]