乌司他丁对婴儿体外循环中细胞粘附分子变化的影响  

Ulinastatin impacts the changes of cell adhesion molecules during infant cardiopulmonary bypass

作　　者：张莉[1] 顾海涛[2] 戚继荣[2] 张斯璧[1] 陈珏[1] 钱燕宁[3] 

机构地区：[1]南京医科大学附属南京儿童医院麻醉科,江苏南京210008 [2]南京医科大学附属南京儿童医院胸外科,江苏南京210008 [3]南京医科大学第一附属医院麻醉科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2008年第10期1305-1308,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:探讨婴儿体外循环中细胞粘附分子的变化及乌司他丁对其的影响。方法:60例1岁以下先心病患儿随机分为乌司他丁组(U组,UTI20000U/kg,溶解于20ml生理盐水中)和对照组(C组,20ml等量生理盐水)。分别在体外循环不同时点采集血样,检测血管内皮细胞粘附分子-1(ICAM-1)和中性粒细胞整合素β-2亚族中的CD11b/CD18的蛋白表达量并观察其变化;检测血气值并计算呼吸指数(RI)。结果:体外循环后两组ICAM-1和CD11b/CD18的表达量均显著增加,RI上升,但乌司他丁组各相应值明显低于对照组(P<0.05)。结论:婴儿体外循环中,ICAM-1、CD11b/CD18和RI值均有明显升高,乌司他丁可减缓此变化过程。Objective：To investigate the changs of cell adhesion molecules and observe the influence with ulinastatin during the infant cardiopulmonary bypass. Methods：Sixty infants with congenital heart disease were randomly divided into two groups：group U （received ulinastatin 20 000 U/kg,dissolved in 20 ml normal saline）,group C （received 20 ml normal saline）. Blood samples were collected in different moments. The proteinum expressions of ICAM-1 and CD1 lb/CD18 were examined,and the variations were observed. The blood gas value and calculated respiratory index （RI） were also detected. Results：The expressions of ICAM-1 and CDllb/ CD18 increased significantly after CPB in two groups with RI rlsing,and increased more obviously in group C than those in group U （P 〈 0.05）. Conclusion：The expressions of ICAM-1 and CDllb/CD18 increased,and RI rose during the CPB in infant. Ulinastatin may relieve the process.

关 键 词：婴儿 体外循环 血管内皮细胞粘附分子-I 整合素β-2亚族(CD1 1b/CD18) 乌司他丁 

分 类 号：R725.4[医药卫生—儿科]