正交实验优选赤芍提取工艺研究  

Optimization of Extracting Procedure for Radix Paeoniae Rubra by Orthgonal Design

作　　者：徐先祥[1] 周丽[1] 马燕[1] 张睿[1] 姜辉[1] 

机构地区：[1]安徽中医学院第一附属医院药学部,安徽合肥230031

出　　处：《安徽中医学院学报》2008年第5期41-43,共3页Journal of Anhui Traditional Chinese Medical College

基　　金：国家自然科学基金项目(30600821);安徽省自然科学基金项目(050431004)

摘　　要：目的:优选乙醇提取赤芍工艺。方法:采用正交实验方法,以芍药苷为指标成分,以乙醇浓度、溶剂量、提取时间、提取次数为考察因素,各设置3个水平,对赤芍乙醇提取工艺进行优化。结果:芍药苷的最佳提取工艺条件为:700 ml/L乙醇,8倍量水,提取3次,每次1.5 h。结论:不同条件对赤芍提取物中芍药苷含量有影响。Objective： To optimize the alcohol-extracting procedure for Radix Paeoniae Rubra. Methods： An orthogonal design was employed. Paeoniflorincontent was used as the indicates. And alcohol content, solvent concentration, extraction time and extraction times were the four factors, which were tested at three levels. Results： The optimal extracting procedure was as follows： extracting three times by using eight times 700 ml/L alcohol, 1.5 hours each time. Conclusion： The different extracting conditions have influences on the contents of paeoniflorin.

关 键 词：赤芍 赤芍苷 提取工艺 正交实验 

分 类 号：R284.2[医药卫生—中药学]