3234名孕妇产前HDN特异性抗体筛查结果分析  

The detection of HDN antibody in 3234 pregnant women before delivery

作　　者：赖福才[1] 王梁平[1] 白英明[2] 彭道波[1] 赵晖[1] 

机构地区：[1]南方医科大学南方医院输血科,广东广州510515 [2]南方医科大学中医药学院中西医结合基础教研室

出　　处：《中国输血杂志》2008年第9期688-689,共2页Chinese Journal of Blood Transfusion

基　　金：广东省医学科研基金课题(编号:A2005411)

摘　　要：目的探讨孕妇血型抗体效价与新生儿溶血病之间的关系。方法按照常规鉴定3 234对产前孕妇与丈夫ABO及RhD血型,采用微柱凝胶法技术检测夫妻ABO血型不合孕妇血清中的IgG抗-A、抗-B及抗-D效价。结果1901名夫妻ABO血型不合,产前抗-A或-B体效价>64的孕妇共1007名;其中O型980名,占97.32%;A型13名,占1.29%;B型14名,占1.39%;夫妻RhD不相合29对(0.90%),其中RhD(+)3例,抗-D效价≥256。结论新生儿溶血病主要发生在O型母亲怀有的A型或B型血胎儿,但并不能排除A或者B型血母亲所怀血型不合的胎儿。应对血型不合夫妇(特别是O型妇女)进行产前IgG抗-A或B效价检查,做到早预防、早治疗。Objective To explore the relationship between the titers of maternal blood group antibodies and the incidence of HDN. Methods The blood samples from 3 234 couples were collected before delivery and the ABO and Rh （ D ） blood type of the samples were identified. The titer of anti-A/B IgG and anti-D in maternal serum were measured by microcolumn gelatum in those pregnant women whose ABO blood group were incompatible to their husbands. Results In the I 901 couples with incompatible ABO blood groups, the percentage of the pregnant women, with the titers ≥64, were 980 {97.32% ） in pregnant women with blood group O, 13（ 1.29% ） in blood group A, and 14{ 1.39% ） in blood group B. In the 29 RhD blood group incompatible couples, there were 3 with anti-D（＋ ）, with the titers≥256. Conclusion Pregnant women with blood type O, who carry fetus with blood type A/B, most likely suffer from HDN majorly. However, HDN may occur in pregnant women with blood type A/B, who have fetus with incompatible blood types. The titer of anti-A/B IgG in couple with incompatible blood type should be detected in order to prevent the HDN.

关 键 词：新生儿溶血病 微柱凝胶技术 血型抗体 效价 

分 类 号：R446.63[医药卫生—诊断学] R772.18[医药卫生—临床医学]