土霉素在大菱鲆体内药代动力学及残留消除规律研究  

Study on Pharmacokinetic and Eliminate of Oxytetracycline in Turbot

作　　者：郑增忍[1] 赵思俊[1] 邹明[2] 路平[1] 李存金[1] 谭维泉[1] 孙晓亮[1] 曲志娜[1] 

机构地区：[1]中国动物卫生与流行病学中心,青岛266032 [2]青岛农业大学动物科技学院,青岛266109

出　　处：《中国农学通报》2008年第10期559-563,共5页Chinese Agricultural Science Bulletin

摘　　要：首次研究大菱鲆口服土霉素的药代动力学特征及残留消除规律。采用高效液相色谱法,对以80mg/kgb.w.单剂量口灌土霉素的大菱鲆进行连续采样监测。结果表明,土霉素在大菱鲆血液、肌肉、肝脏中药代动力学特征分别符合带时滞的一级吸收二室开放模型、带时滞的一级吸收二室开放模型和带时滞的一级吸收一室开放模型。土霉素在大菱鲆体内消除速度较慢,16℃水温的实验条件下,在大菱鲆肌肉、肝脏中的休药期分别为28d和10d。This article is the first to study on pharmacokinetic and eliminate of OTC in turbot after oral administration. The residue of OTC in turbot which was exposured to 80mg/kg b.w. OTC solution was monitored continually by HPLC. Pharmacokinetic studies showed that the concentration-time course of the drug conformed to the characteristics of the two compartment open model with the first order absorption and a lagtime for the blood and the muscle, and the one compartment open model with first order absorption and a lagtime for the liver. OTC was slowly eliminated in turbot. The concentration of OTC in the muscle was below LOD after 28d, and the concentration of OTC in the liver was below LOD after 10d.

关 键 词：土霉素 大菱鲆 药代动力学 消除 高效液相色谱法 

分 类 号：S948[农业科学—水产养殖]