急性播散性脑脊髓炎患儿脑脊液β_2-微球蛋白水平动态观察的临床分析  

Clinical analysis on the dynamic observation of β_2-microglobulin level in patients' cerebrospinal fluid having acute disseminated encephalomyelitis

作　　者：闫一兵[1] 孙文英[1] 杨春燕[1] 

机构地区：[1]山东省聊城市人民医院儿科,山东聊城252000

出　　处：《中日友好医院学报》2008年第5期285-287,共3页Journal of China-Japan Friendship Hospital

摘　　要：目的:探讨急性播散性脑脊髓炎(ADEM)患儿脑脊液β2-微球蛋白(β2-MG)水平的变化及其临床意义。方法:采用放射免疫分析法对38例ADEM患儿的脑脊液β2-MG水平分别于发病后第1～4d、10～14d及1个月进行检测,与40例无神经系统疾病而需外科手术的腰麻患儿脑脊液中β2-MG水平进行对比分析。比较轻症组与重症组、有后遗症组与无后遗症组脑脊液β2-MG水平的差异。结果:38例患儿中有35例(92.1%)脑脊液中β2-MG病程初期(1～4d)即较对照组显著增高(P<0.05);重症组脑脊液中β2-MG显著高于轻症组(P<0.05),有后遗症组脑脊液中β2-MG显著高于无后遗症组(P<0.05);恢复期脑脊液β2-MG逐渐下降,重症组及有后遗症组恢复较慢,病程1个月时脑脊液中β2-MG水平仍显著高于对照组(P<0.05)。结论:ADEM患儿脑脊液β2-MG变化出现早,异常率高,具有重要的早期诊断价值;动态检测脑脊液β2-MG的变化,有助于判定病情严重程度及评估患儿的预后。Objective：To study the dynamic change of β2-microglobulin （β2-MG）level in patients＇ eerebrospinal fluid（CSF）having acute disseminated eneephalomyelitis（ADEM）and the clinical significance.Methods：The levels of β2-MG in CSF were detected at the day 1-4, 10-14 and one month in 38 patients having ADEM by radio immunoassay and were contrasted with 40 cases non-nervous system disease but needing surgery under lumbar anesthesia children.And at the same time we compared the difference of β2-MG between the mild case and severe case,having sequela and no sequela.Results：At early course of disease （day 1-4）,the level of β2- MG in CSF increased significantly which existed significant difference（P〈0.05）,the level of β2-MG in CSF in severe case and in sequela case was higher （P〈0.05）.At convalescence stage,the level of β2-MG decreased gradually.While in sequela case,the convalescence was slower and the level of β2-MG in CSF still remained higer after one month.Conclusion：The level of β2-MG in patients＇ CSF having ADEM was relevant with the disease.Dynamic detection of β2-MG level can be taken as an important index to evaluate the clinical significance and prognosis in ADEM patients.

关 键 词：急性播散性脑脊髓炎脑脊液 Β2-微球蛋白 早期诊断 预后 

分 类 号：R725.1[医药卫生—儿科]