Tumor necrosis factor-α： a new mechanism of ischemic ventricular fibrillation？  

作　　者：XIAO Hua LIAO Yu-hua CHEN Zhi-jian 

机构地区：[1]Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China

出　　处：《Chinese Medical Journal》2008年第18期1848-1851,共4页中华医学杂志（英文版）

基　　金：This work was supported by grants from the National Basic Research Program of China （973 Program） （No. 2007CB512005） and National Natural Science Foundation of China （NSFC） （No. 30770880）.

摘　　要：Ventricular fibrillation （VF） in myocardial ischemia is called ＂ischemic VF＂. As a severe morbid state and a leading cause of sudden cardiac attack, ischemic VF induces approximately 3 million deaths in the United States each year. Ischemic VF is caused by ＂triggers＂ such as ventricular premature beat or ventricular tachycardia in the presence of a suitable ＂substrate＂. The triggers frequently occur at the border zone and the substrate is required for the maintenance of ischemic VE The critical factors for the initiation and maintenance of ischemic VF are obscure. Tumor necrosis factor-α （TNF-α）, an inflammatory cytokine expressed in myocardial ischemia, plays an important role in the pathophysiological process of acute myocardial infarction （AMI）. TNF-α also causes arrhythmia by action potential prolongation and abnormal Ca^2＋ handling, which also contribute to ischemic VE But the relationship between TNF-α and ischemic VF is unknown. In this article, we suggest that TNF-α may be a novel substrate of ischemic VE This may be a new mechanism for ischemic VF.Ventricular fibrillation （VF） in myocardial ischemia is called ＂ischemic VF＂. As a severe morbid state and a leading cause of sudden cardiac attack, ischemic VF induces approximately 3 million deaths in the United States each year. Ischemic VF is caused by ＂triggers＂ such as ventricular premature beat or ventricular tachycardia in the presence of a suitable ＂substrate＂. The triggers frequently occur at the border zone and the substrate is required for the maintenance of ischemic VE The critical factors for the initiation and maintenance of ischemic VF are obscure. Tumor necrosis factor-α （TNF-α）, an inflammatory cytokine expressed in myocardial ischemia, plays an important role in the pathophysiological process of acute myocardial infarction （AMI）. TNF-α also causes arrhythmia by action potential prolongation and abnormal Ca^2＋ handling, which also contribute to ischemic VE But the relationship between TNF-α and ischemic VF is unknown. In this article, we suggest that TNF-α may be a novel substrate of ischemic VE This may be a new mechanism for ischemic VF.

关 键 词：ischemic ventricular fibrillation tumor necrosis factor-alpha arrhythmias  cardiac 

分 类 号：R541.7[医药卫生—心血管疾病]