Dynamic gadoteridol-enhanced MR imaging in the end of growing long bone of piglets  

作　　者：LI Xiao-ming XIONG Wei HU Dao-yu YU Cheng PENG Wen-jia HU Jun-wu FENG Ding-yi HU Xue-mei LI Hong-lian QIU Li LI Feng 

机构地区：[1]Department of Radiology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China [2]Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China [3]Department of Histology Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China [4]Department of Statistics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

出　　处：《Chinese Medical Journal》2008年第19期1932-1938,共7页中华医学杂志（英文版）

摘　　要：Background It is of value to identify the non-invasive means that can accurately reflect the blood supply of epiphysis and is more sensitive in detection of early ischemia of epiphysis than the conventional gadoteridol （Gd）-enhanced SE TlWI. The aim of this study was to evaluate the blood supply of various anatomic regions at the end of normal growing long bone using dynamic Gd-enhanced MR imaging and compare the sensitivities between dynamic Gd-enhanced MR imaging and conventional Gd-enhanced SE TlWl in the detection of decreased blood perfusion of early epiphyseal ischemia. Methods Twenty-seven two-week-old piglets were used in this study. For the study of the end of normal growing long bone, unilateral MR imaging of the distal femur and proximal tibia was performed on eleven piglets. The comparison was made among various anatomic regions （physeal and epiphyseal cartilage, metaphyseal spongiosa, the secondary ossification center and metaphysis） using MRI in terms of the enhancement ratio and speed. Their relationships with the histological findings, including RBC/mm^2 and vessel distribution, were evaluated. To examine ischemic femoral head, 16 piglets were divided into two groups, with the control group having 8 piglets （involving 16 normal hips） and an ischemic group having 8 piglets （involving 16 hips with hyperabduction）. In the ischemic group, MR imaging was performed on the hips in the hyperabduction immobilized persistently for 30 minutes. After MRI, the piglets were allowed to ambulate freely for 1 day and the same MR scanning was then repeated in a neutral position. The difference in enhancement ratio and speed of the femoral head between the control and ischemic group were evaluated. Results With regard to the end of normal growing long bone, the enhancement ratio of the metaphyseal spongiosa was greatest among all the anatomic regions （P 〈0.001）. The enhancement ratio of physeal cartilage was greater than that of epiphyseal cartilage （P 〈0. 001）, which was the lowest in alBackground It is of value to identify the non-invasive means that can accurately reflect the blood supply of epiphysis and is more sensitive in detection of early ischemia of epiphysis than the conventional gadoteridol （Gd）-enhanced SE TlWI. The aim of this study was to evaluate the blood supply of various anatomic regions at the end of normal growing long bone using dynamic Gd-enhanced MR imaging and compare the sensitivities between dynamic Gd-enhanced MR imaging and conventional Gd-enhanced SE TlWl in the detection of decreased blood perfusion of early epiphyseal ischemia. Methods Twenty-seven two-week-old piglets were used in this study. For the study of the end of normal growing long bone, unilateral MR imaging of the distal femur and proximal tibia was performed on eleven piglets. The comparison was made among various anatomic regions （physeal and epiphyseal cartilage, metaphyseal spongiosa, the secondary ossification center and metaphysis） using MRI in terms of the enhancement ratio and speed. Their relationships with the histological findings, including RBC/mm^2 and vessel distribution, were evaluated. To examine ischemic femoral head, 16 piglets were divided into two groups, with the control group having 8 piglets （involving 16 normal hips） and an ischemic group having 8 piglets （involving 16 hips with hyperabduction）. In the ischemic group, MR imaging was performed on the hips in the hyperabduction immobilized persistently for 30 minutes. After MRI, the piglets were allowed to ambulate freely for 1 day and the same MR scanning was then repeated in a neutral position. The difference in enhancement ratio and speed of the femoral head between the control and ischemic group were evaluated. Results With regard to the end of normal growing long bone, the enhancement ratio of the metaphyseal spongiosa was greatest among all the anatomic regions （P 〈0.001）. The enhancement ratio of physeal cartilage was greater than that of epiphyseal cartilage （P 〈0. 001）, which was the lowest in al

关 键 词：gadoteridol contrast enhancement growing bone blood supply 

分 类 号：R331.3[医药卫生—人体生理学]