药用壳聚糖磁性复合微球的制备及特性  

Preparation and Characteristics of Composite Magnetic Chitosan Microspheres Used as Carrier of Targeted-drug

作　　者：赵原璧[1] 邱祖民[1] 刘钟薇[1] 黄佳英[1] 

机构地区：[1]南昌大学环境科学与工程学院,南昌330031

出　　处：《材料工程》2008年第10期358-362,共5页Journal of Materials Engineering

基　　金：江西教育厅科技计划资助项目(赣教技字[2006]11号);江西省主要学科学术和技术带头人培养对象(赣科发计字[2006]155号);江西省自然科学基金资助项目(0620060)

摘　　要：采用化学共沉淀法,以FeC12.4H2O和FeCl3.6H2O为原料,氨水为沉淀剂制备出磁性Fe3O4纳米粒子;然后采用化学交联法,在分散有纳米Fe3O4的壳聚糖乳液中,加入适量的戊二醛交联剂制得包覆有纳米Fe3O4的壳聚糖复合微球载体。该复合磁性微球成球性好,分散均匀,平均粒径达到10μm左右,具有较好的磁响应性及生物可降解特性。该复合磁性微球可作为载体材料应用于磁性靶向药物的制备。Using FeCl3· 6H2O and FeCl2 ·4H2O as reactants and NH4 OH as precipitation reagent, the magnetic Fe3O4 nanoparticles were prepared by chemical co-precipitation. And then using the e- mulsification cross-linking technique to got composite magnetic chitosan microspheres was got by adding proper amount of glutaraldehyde into chitosan solution which contains dispersed Fe3O4 nanop- articles. The average size of prepared composite magnetic microsphere was about 10μm, due to the spherical, dispersive, magnetic-responsive and biodegradable characteristic, the composite magnetic chitosan microsphere can be used as functional material or carrier for targeted delivery of drugs.

关 键 词：磁性FE3O4纳米粒子 化学共沉淀法 乳化交联法 复合微球 

分 类 号：R944.27[医药卫生—药剂学] R979.1[医药卫生—药学]