在体磁共振成像研究脑铁含量是否存在性别差异  

Are there gender differences in iron contents of adult brain:an in vivo susceptibility weighted imaging study

作　　者：徐晓俊[1] 汪启东[1] 张敏鸣[1] 

机构地区：[1]浙江大学医学院附属第一医院放射科,浙江杭州310003

出　　处：《浙江大学学报（医学版）》2008年第5期477-482,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金资助项目(30570536)

摘　　要：目的：采用磁敏感加权相位成像技术对一组健康成年志愿者进行脑铁成像,研究男性和女性的脑内铁含量是否存在差异。方法：78位年龄在22-78岁的成年健康志愿者接受磁敏感加权成像扫描。其中男性40人,年龄（41.5±11.9）岁;女性38人,年龄（45.2±15.9）岁。在校正相位图上分别测量苍白球、壳核、尾状核、黑质、红核、丘脑和额叶白质的相位值。30岁以上受试者各脑区的平均相位值与文献报道的30岁以上成年人脑铁实际含量进行Pearson相关分析,以验证测量资料的可靠性。运用协方差模型分析各脑区铁含量是否存在性别差异,其中年龄作为协变量,以控制年龄对脑铁含量的影响。结果：各脑区的平均相位值和文献报道的脑铁实际含量间存在负相关性（r=-0.796,P=0.032）。在所关注的各脑区中,男性和女性的铁含量统计学上均未见显著性差异（P〉0.05）。结论：成年人的脑铁含量没有性别差异。Objective： To investigate the gender-related difference in the iron contents of the human brain. Methods： The brain iron levels were evaluated in vivo in 78 healthy adult volunteers using a noninvasive magnetic resonance method termed susceptibility weighted phase imaging. The subjects consisted of 40 males and 38 females,with the mean age of 41.5±11.9 and 45.2±15.9,respectively. The phase values were measured on the corrected phase images in the globus pallidus,putamen,caudate,substantia nigra,red nucleus,thalamus and frontal white matter. Phase values of these regions measured from the subjects aged over 30 were correlated with published values of brain iron contents in normal adults to check the validity of the data. Covariance models were used to evaluate the gender effect on the brain iron concentration,with age as the covariate,controlling for the linear effects of age. Results： A strongly negative correlation was showed between the phase values of this study and the reference values （r=-0.796,P=0.032）. No significant gender-related difference in the brain iron concentration was found in any regions of interest （P〉0.05）. Conclusion： Gender differences in the iron contents of the adult human brain are not found in this study.

关 键 词：脑化学 铁/分析 磁共振成像/方法 性别因素 中枢神经系统/解剖学和组织学 

分 类 号：R445.2[医药卫生—影像医学与核医学]