阿托伐他汀早期干预对非ST抬高型急性冠脉综合征患者血清高敏C反应蛋白和妊娠相关血浆蛋白-A水平的影响  

Effect of early atorvastatin therapy on serum hs-CRP and PAPP-A levels in acute coronary syndrome with non-ST-segment elevation

作　　者：方阅[1] 刘皋林[1] 方敏[1] 

机构地区：[1]上海市第一人民医院药剂科,上海市200080

出　　处：《中华实用诊断与治疗杂志》2008年第10期721-723,共3页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的:探讨阿托伐他汀早期干预治疗对非ST抬高型急性冠脉综合征患者血清高敏C反应蛋白和妊娠相关血浆蛋白-A水平的影响。方法:采用酶联免疫吸附法测定不稳定型心绞痛患者(UAP组)、急性心肌梗死患者(AMI组)、稳定型心绞痛患者(SAP组)和健康体检者的高敏C反应蛋白和妊娠相关血浆蛋白-A水平。同时将急性冠脉综合征患者(包括UAP和AMI组)随机分为常规治疗组和阿托伐他汀干预组(阿托伐他汀20 mg/d),并于治疗前后分别测定血清高敏C反应蛋白和妊娠相关血浆蛋白-A水平。结果:(1)高敏C反应蛋白和妊娠相关血浆蛋白-A水平在UAP组、AMI组比SAP组、正常对照组显著升高(P<0.05)。(2)2周后,阿托伐他汀干预组血清高敏C反应蛋白和妊娠相关血浆蛋白-A水平较治疗前明显降低,且较常规治疗组治疗2周后亦有显著降低。结论:阿托伐他汀干预可以减少急性冠脉综合征患者动脉粥样硬化斑块的炎症反应,具有稳定斑块的作用。Objective To investigate the effects of atorvastatin on serum high sensitive C-reactive protein and pregnancy-associated plasma protein-A levels in the early phase of acute coronary syndrome with non-ST-segment elevation. Methods Serum high sensitive C-reactive protein and pregnancy-associated plasma protein A levels were measured in patients with unstable angina pectoris, patients with acute myocardial infarction, patients with stable angina pectoris, and healthy controls. The patients with acute coronary syndrome including unstable angina pectoris and acute myocardial infarction were randomly divided into conventional treatment group and atorvastatin treatment group. Serum high sensitive C-reactive protein and pregnancy associated plasma protein-A levels were detected before and after treatment. Results Serum high sensitive C-reactive protein and pregnancyassociated plasma protein-A levels in patients with acute coronary syndrome were significantly higher than those in stable angina patients and controls （all P〈0. 05）. Serum high sensitive C-reactive protein and pregnancy-associated plasma protein-A levels significantly decreased after atorvastatin treatment in patients with acute coronary syndrome compared with baseline and were also lower compared with conventional treatment group. Conclusion Atorvastatin can reduce inflammatory reaction in atherosclerotic plaque in patients with acute coronary syndrome and has an effect on plaque stabilization.

关 键 词：急性冠脉综合征 阿托伐他汀 高敏C反应蛋白 妊娠相关血浆蛋白-A 炎症 

分 类 号：R541.4[医药卫生—心血管疾病]